4-Chloro-3-fluoroaniline CAS 367-22-6

1. Acts as a critical intermediate for synthesizing antimalarial and anti-inflammatory fluorinated pharmaceutical ingredients.
2. Serves 4-Chloro-3-fluoroaniline CAS 367-22-6 as a core building block for manufacturing high-efficiency agrochemicals like herbicides and fungicides.
3. Functions as a reactive substrate for diazotization and coupling reactions in fine organic synthesis and heterocyclic chemistry.
4. Serves 4-Chloro-3-fluoroaniline as a precursor for producing specialty materials such as organic dyes and electronic intermediates.

1. Store in sealed amber glass containers at 10–25℃ in a cool, dry and well-ventilated area away from direct sunlight.
2. Keep 4-Chloro-3-fluoroaniline separated from strong oxidants, acids and halogens to avoid decomposition and toxic fume emission.
3. Wear nitrile gloves, chemical safety goggles and a vapor respirator during handling, weighing and transfer.
4. Avoid 4-Chloro-3-fluoroaniline skin/eye contact; dispose of waste through licensed hazardous chemical disposal services.

1. Chloro-fluoro substitution enhances electrophilicity and reaction selectivity for efficient synthetic modifications.
2. Enables 4-Chloro-3-fluoroaniline production of fluorinated pharmaceuticals with improved metabolic stability and target binding affinity.
3. Shows good solubility in organic solvents like methanol and toluene, adapting to diverse reaction systems.
4. Offers 4-Chloro-3-fluoroaniline high purity and consistent reactivity, suitable for lab-scale R&D and industrial mass production.

This chemical is classified as an irritant (Xi) with hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). 4-Chloro-3-fluoroaniline is incompatible with strong oxidizers, acids and anhydrides; improper mixing can release toxic chlorine/fluorine-containing fumes. Prolonged skin contact leads to redness and burns, while vapor inhalation may cause respiratory discomfort. 4-Chloro-3-fluoroaniline is a hazardous chemical with UN number 2811 (Packing Group III).