Ethyl Dichlorophosphate CAS 1498-51-7

1. Ethyl dichlorophosphate CAS 1498-51-7 is primarily used as a phosphorylating and chlorinating agent in organic synthesis, particularly for producing phosphate esters, phosphoramidates, and other organophosphorus compounds.
2. Ethyl dichlorophosphate serves as a key intermediate in the manufacture of agrochemicals (e.g., insecticides, herbicides), flame retardants, and plasticizers.
3. Ethyl dichlorophosphate functions as a reagent in peptide synthesis, nucleotide chemistry, and the preparation of chiral ligands for catalysis.

1. Store ethyl dichlorophosphate CAS 1498-51-7 in a cool, dry, well-ventilated area, in tightly sealed, corrosion-resistant containers under an inert atmosphere (e.g., nitrogen or dry argon) to prevent hydrolysis and degradation.
2. Keep ethyl dichlorophosphate strictly separate from water, alcohols, amines, strong bases, oxidizing agents, and reactive chemicals to avoid violent exothermic reactions, toxic gas release (e.g., HCl, phosphine), or hazardous decomposition.
3. Handle ethyl dichlorophosphate with extreme care using non-sparking tools and grounded equipment; ensure containers are clearly labeled as corrosive, moisture-sensitive, and toxic.

1. Immediately evacuate and isolate the spill area, eliminate all ignition sources, and ensure forced ventilation; avoid any contact with water or moisture during containment.
2. Carefully absorb spilled ethyl dichlorophosphate with dry sand or other inert, non-combustible material; collect into sealed, corrosion-resistant containers for disposal as hazardous waste.
3. Neutralize residual acid with a suitable alkaline material (e.g., sodium bicarbonate) only if trained and equipped to do so safely; clean the contaminated surface with a dry method or appropriate solvent, and dispose of all waste according to stringent hazardous material regulations for toxic and corrosive substances.

1. Ethyl dichlorophosphate CAS 1498-51-7 is corrosive and causes severe skin burns, eye damage, and respiratory tract irritation upon contact or inhalation of vapors/mists; it reacts violently with water to release corrosive and toxic gases.
2. Ethyl dichlorophosphate is toxic if swallowed, inhaled, or absorbed through the skin, and may cause systemic effects (e.g., neurotoxicity) with acute or repeated exposure; it is a lachrymator and may be fatal if inhaled.
3. Always handle ethyl dichlorophosphate in a certified fume hood or closed system, wearing appropriate PPE including acid-resistant gloves, face shield, chemical goggles, and protective clothing; use supplied-air respiratory protection and ensure emergency washing facilities are accessible.