Iodobenzene CAS 591-50-4

1. Iodobenzene CAS 591-50-4 is used as a versatile building block to form Grignard reagents for introducing phenyl groups and participates in cross-coupling reactions like Sonogashira and Heck to form complex molecules .
2. Iodobenzene acts as a catalyst or reagent in organic synthesis to enable oxidation and cyclization reactions, and serves as a substrate in the synthesis of biphenyl and stilbene .
3. Iodobenzene is employed industrially as an intermediate for producing pharmaceuticals and liquid crystal materials, and as a standard for refractive index measurements .

1. Store Iodobenzene CAS 591-50-4 in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light, as Iodobenzene is light sensitive and tends to discolor upon exposure .
2. Keep Iodobenzene away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents and magnesium .
3. Handle Iodobenzene using appropriate personal protective equipment including chemical-resistant gloves and safety goggles, and ensure adequate ventilation or use a fume hood to avoid breathing vapors .

1. Isolate the spill area, eliminate all ignition sources, and contain liquid Iodobenzene CAS 591-50-4 using dry inert absorbent material like sand, preventing entry into drains or waterways .
2. Collect absorbed Iodobenzene using non-sparking, explosion-proof tools into sealed, labeled containers for disposal according to environmental regulations .
3. Personnel cleaning Iodobenzene spills must wear full protective equipment including suitable respirator and ensure adequate ventilation during cleanup .

1. Iodobenzene CAS 591-50-4 is harmful if swallowed (H302) and causes serious eye irritation (H319), with GHS signal word "Warning" and rat oral LD50 of 1799 mg/kg .
2. Iodobenzene is a combustible liquid (H227) with a flash point of 74-77°C; combustion produces toxic fumes including carbon monoxide, carbon dioxide, and hydrogen iodide .
3. Iodobenzene may cause skin and respiratory tract irritation upon contact or inhalation, and is stable under normal temperatures but incompatible with strong oxidizing agents .