5-Aminoindole CAS 5192-03-0

1. 5-Aminoindole is primarily used as a key building block in pharmaceutical development, particularly for synthesizing anti-cancer agents, antivascular agents, and HIV protease inhibitors due to its ability to interact with biological targets .
2. 5-Aminoindole CAS 5192-03-0 serves as a reactant for preparing various bioactive molecules, including Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP, insulin-like growth factor 1 receptor inhibitors, and PKCθ inhibitors .
3. 5-Aminoindole is employed in organic synthesis for creating indole-derived heterocycles, fluorescent materials, and dyes, and has applications in hydrophobic charge-induction chromatography (HCIC) as an adsorbent .
4. Researchers utilize 5-Aminoindole CAS 5192-03-0 in the development of fluorescent probes for imaging applications and in material science for creating polymers with enhanced properties such as conductivity and thermal stability .

1. 5-Aminoindole must be stored in a tightly sealed container under inert atmosphere (nitrogen or argon) in a cool, dry, and well-ventilated environment, protected from light and air as it is light and air sensitive .
2. Recommended storage temperatures range from 2-8°C (refrigerator) for short-term stability to -20°C for long-term storage (up to 3 years), with the product stable for 2 years at 4°C .
3. 5-Aminoindole CAS 5192-03-0 is classified with GHS hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" according to TCI and "Danger" according to Sigma-Aldrich .
4. Personnel must wear chemical-resistant gloves, tightly fitting safety goggles with side-shields, and protective clothing when handling 5-aminoindole, avoiding formation of dust and aerosols, and working in well-ventilated areas with spark-proof tools .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 5-aminoindole is released, evacuating non-essential personnel .
2. Collect 5-Aminoindole CAS 5192-03-0 by vacuuming or sweeping without creating dust using non-sparking tools, or absorb with inert materials, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, decontaminate surfaces using appropriate methods, and prevent the product from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with flue gas scrubbing, noting UN2811 classification .

1. 5-Aminoindole is combustible with a flash point of approximately 195°C and boiling point of 354°C at 760 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide, and irritating gases .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use water jet as it may scatter burning material .
3. Firefighters 5-Aminoindole CAS 5192-03-0 should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-aminoindole due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination and pollution .