L-Histidine Hydrochloride CAS 1007-42-7

1. L-Histidine hydrochloride is an essential amino acid used as a dietary supplement to support protein synthesis, tissue repair, and the production of histamine, which plays a role in immune response and gastric acid secretion .
2. L-Histidine hydrochloride CAS 1007-42-7 serves as a critical component in cell culture media for the production of monoclonal antibodies and recombinant proteins, supporting optimal cell growth and protein expression .
3. L-Histidine hydrochloride is employed as a building block in peptide synthesis and pharmaceutical manufacturing, and is used as a reference standard in amino acid analysis for quality control applications .
4. Researchers utilize L-Histidine hydrochloride CAS 1007-42-7 in studies of histidine metabolism, metal chelation, and as a buffer component in biochemical assays due to its imidazole side chain with a pKa near physiological pH .

1. L-Histidine hydrochloride must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; powder is stable for up to 3 years at -20°C or 2 years at 4°C .
2. L-Histidine hydrochloride CAS 1007-42-7 is classified as non-hazardous under normal handling conditions according to GHS criteria, but may cause mild skin, eye, and respiratory tract irritation .
3. Personnel should wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents; for solution storage, prepare aliquots and use within 1 month at -20°C, avoiding repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when L-Histidine hydrochloride is released .
2. Collect L-Histidine hydrochloride CAS 1007-42-7 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport (DOT, IATA, IMDG) .

1. L-Histidine hydrochloride is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as L-Histidine hydrochloride CAS 1007-42-7 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning L-Histidine hydrochloride due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .