3-Aminobenzotrifluoride CAS 98-16-8

1. 3-Aminobenzotrifluoride is a key intermediate in the pharmaceutical industry for synthesizing a range of active ingredients, including the diuretic bendroflumethiazide, the anti-androgen bicalutamide, the analgesic niflumic acid, and the glaucoma agent travoprost .
2. 3-Aminobenzotrifluoride CAS 98-16-8 serves as a crucial building block for producing herbicides such as flurochloridone and fluometuron, and the veterinary analgesic flunixin .
3. Applications of 3-Aminobenzotrifluoride also include its use in the synthesis of fungicides and other specialty chemicals, leveraging the unique electronic properties of its trifluoromethyl group .

1. Store 3-Aminobenzotrifluoride in a tightly sealed container under an inert gas in a cool, dry, and well-ventilated place, protected from light and away from heat and open flames. Recommended storage is in a cool, dark place below 15°C or at -20°C for long-term stability .
2. Keep 3-Aminobenzotrifluoride strictly away from strong oxidizing agents, as it is incompatible, and avoid contact with air and light due to its sensitivity .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves (e.g., fluorinated rubber), protective clothing, and eye/face protection. Use only with adequate ventilation or in a fume hood to avoid breathing vapors, mist, or dust .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation. Contain 3-Aminobenzotrifluoride using inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully collect the contaminated material using an electrically protected vacuum cleaner or by wet-brushing and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-resistant clothing and self-contained breathing apparatus (SCBA) during cleanup. For large spills, construct a dike to contain the material before collection . 3-Aminobenzotrifluoride is classified for transport (UN2948, Hazard Class 6.1, PG II) .

1. 3-Aminobenzotrifluoride is classified as a combustible liquid (H227) that is fatal if inhaled (H330), harmful if swallowed (H302), and toxic if absorbed through the skin (H311). 3-Aminobenzotrifluoride CAS 98-16-8 causes skin irritation (H315) and serious eye damage (H318), and may cause damage to organs through prolonged or repeated exposure (H373) .
2. 3-Aminobenzotrifluoride is very toxic to aquatic life with long-lasting effects (H410/H411) . Its thermal decomposition or combustion produces toxic and irritating fumes including carbon monoxide, nitrogen oxides, and hydrogen fluoride . Acute oral toxicity (rat) LD50 is 480 mg/kg .
3. Always consult 3-Aminobenzotrifluoride CAS 98-16-8 the specific Safety Data Sheet (SDS) for 3-Aminobenzotrifluoride for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P301+P312+P330 for ingestion, P303+P361+P353 for skin), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P260 (do not breathe vapors), P273 (avoid release to environment), and P280 (wear protective gloves/eye protection) .