3-(Trifluoromethyl)benzaldehyde CAS 454-89-7

1. 3-(Trifluoromethyl)benzaldehyde CAS 454-89-7 is primarily used as a key intermediate in the synthesis of pharmaceuticals, notably for developing anti-inflammatory, analgesic, and anti-tumor agents, including HIF-1 inhibitors and potential antitumor γ-butyrolactones . It is also utilized as an intermediate for agrochemical formulations such as pesticides and herbicides .
2. 3-(Trifluoromethyl)benzaldehyde serves as a valuable reagent in organic synthesis and medicinal chemistry for creating complex molecules via condensation, reduction, and nucleophilic addition reactions, taking advantage of its reactive aldehyde moiety and the electron-withdrawing trifluoromethyl group .
3. Applications of 3-(Trifluoromethyl)benzaldehyde also include its use in material science for developing advanced materials, polymers, and coatings, and as a building block for creating electron-transport materials due to the stability and electronic properties imparted by the trifluoromethyl group .

1. Store 3-(Trifluoromethyl)benzaldehyde CAS 454-89-7 in a tightly sealed container under an inert atmosphere in a cool, dry, and well-ventilated area, away from heat, sparks, and open flames. Recommended storage temperatures range from refrigeration (2-8 °C) to a cool, dark place, and it must be protected from air and light exposure .
2. Keep 3-(Trifluoromethyl)benzaldehyde away from strong oxidizing agents and reducing agents due to its incompatibility, and take measures to prevent the build-up of electrostatic charge. Do not expose to air .
3. Always use 3-(Trifluoromethyl)benzaldehyde appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing; use only with adequate ventilation or in a fume hood and avoid breathing vapors, mist, or gas when handling 3-(Trifluoromethyl)benzaldehyde .

1. Immediately isolate the spill area, eliminate all ignition sources, and provide adequate ventilation. Contain 3-(Trifluoromethyl)benzaldehyde CAS 454-89-7 using inert, non-combustible absorbent material and prevent entry into drains or waterways .
2. Carefully collect 3-(Trifluoromethyl)benzaldehyde using spark-proof tools and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-resistant clothing and self-contained breathing apparatus (SCBA) during cleanup. 3-(Trifluoromethyl)benzaldehyde is classified for transport and requires hazardous waste disposal .

1. 3-(Trifluoromethyl)benzaldehyde CAS 454-89-7 is classified as a combustible liquid (H227) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). 3-(Trifluoromethyl)benzaldehyde is harmful if swallowed (H302) .
2. 3-(Trifluoromethyl)benzaldehyde is very toxic to aquatic life with long-lasting effects (H400); thermal decomposition or combustion produces toxic and irritating fumes including carbon monoxide, carbon dioxide, and hydrogen fluoride . The flash point is 68 °C (155 °F) .
3. Always consult 3-(Trifluoromethyl)benzaldehyde CAS 454-89-7 the specific Safety Data Sheet (SDS) for 3-(Trifluoromethyl)benzaldehyde for complete hazard information, first-aid procedures, and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P260 (do not breathe vapors), P273 (avoid release to environment), and P280 (wear protective gloves/eye protection) .