3-Chloropivaloyl Chloride CAS 4300-97-4

1. 3-Chloropivaloyl chloride CAS 4300-97-4 is primarily used as an acylating agent and intermediate in organic synthesis, particularly for pharmaceuticals, agrochemicals, and fine chemicals.
2. 3-Chloropivaloyl chloride serves as a key reagent for introducing the 3-chloropivaloyl group into target molecules, such as in the synthesis of β-lactam antibiotics.
3. This compound is also utilized in polymer chemistry and materials science.

1. Store 3-chloropivaloyl chloride CAS 4300-97-4 in a cool, dry, well-ventilated place, away from heat, moisture, and incompatible materials (water, alcohols, bases, oxidizing agents). Use airtight containers under an inert atmosphere if possible.
2. Keep the container tightly sealed and clearly labeled. Handle and open containers only in a dry environment (e.g., glovebox or using dry techniques) to prevent violent hydrolysis.
3. Handle 3-Chloropivaloyl chloride with extreme caution using appropriate personal protective equipment (PPE): chemical-resistant gloves, safety goggles, face shield, and an acid-resistant lab coat. Always use a fume hood.

1. Immediately evacuate and isolate the area. Ensure ventilation and wear full protective gear (gloves, goggles, protective clothing, respirator suitable for acid vapors).
2. **Do NOT use water.** Carefully cover or contain the spill with an inert, dry absorbent material. Place all contaminated material in a sealed, labeled hazardous waste container.
3. Prevent 3-Chloropivaloyl chloride from entering drains, sewers, or the environment. Decontaminate tools and surfaces with a dry inert material first, then carefully clean with a non-aqueous solvent if necessary. Seek expert assistance.

1. 3-Chloropivaloyl chloride CAS 4300-97-4 is **highly corrosive and moisture-sensitive**. It causes severe skin burns, eye damage, and respiratory damage. It is harmful if swallowed or inhaled. Reacts violently with water, alcohols, and bases, releasing heat and toxic/corrosive gases (hydrogen chloride, pivalic acid derivatives).
2. 3-Chloropivaloyl chloride is flammable and may emit highly toxic and corrosive fumes (hydrogen chloride, phosgene, carbon oxides) when heated to decomposition.
3. Always consult the official 3-chloropivaloyl chloride Safety Data Sheet (SDS) and handle it as a severe health, corrosion, and reactivity hazard. Specialized training and procedures for acid chlorides are required.