4-Fluorobenzonitrile CAS 1194-02-1

1. 4-Fluorobenzonitrile CAS 1194-02-1 is a versatile aromatic building block extensively utilized in pharmaceutical development, including the synthesis of kinase inhibitors and opioid receptor antagonists .
2. 4-Fluorobenzonitrile plays a key role in synthesizing agrochemicals and specialty chemicals, and serves as a crucial precursor for advanced materials like liquid crystals and polymers .
3. 4-Fluorobenzonitrile participates in metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Sonogashira couplings, to construct complex molecular architectures .

1. Store 4-Fluorobenzonitrile CAS 1194-02-1 in a tightly sealed container in a cool, dry, and well-ventilated area, away from heat and incompatible substances .
2. Keep 4-Fluorobenzonitrile strictly separated from strong oxidizing agents, strong acids, and strong bases to prevent hazardous decomposition .
3. Handle 4-Fluorobenzonitrile using appropriate personal protective equipment including gloves, safety goggles, and in a fume hood to avoid breathing dust and vapors .

1. Isolate the spill 4-Fluorobenzonitrile CAS 1194-02-1 area, avoid dust formation, and sweep up solid 4-Fluorobenzonitrile into sealed, labeled containers for disposal .
2. Prevent spilled 4-Fluorobenzonitrile from entering drains or waterways, as discharge into the environment must be strictly avoided .
3. Personnel cleaning 4-Fluorobenzonitrile spills must wear suitable protective equipment and dispose of waste according to hazardous material regulations.

1. 4-Fluorobenzonitrile CAS 1194-02-1 is harmful if swallowed (H302), in contact with skin (H312), or if inhaled (H332), and causes skin and serious eye irritation.
2. 4-Fluorobenzonitrile has a flash point of 65°C and is combustible; its thermal decomposition produces toxic fumes including carbon monoxide, hydrogen fluoride, nitrogen oxides, and cyanide fumes .
3. 4-Fluorobenzonitrile is classified with GHS signal word "Warning" and requires handling with precautionary statements P261 (avoid breathing dust), P280 (wear protective gloves/eye protection), and P305+P351+P338 (if in eyes) .