4-Fluoronitrobenzene CAS 350-46-9

1. 4-Fluoronitrobenzene CAS 350-46-9 is a key pharmaceutical intermediate for synthesizing anticancer N-aryl-L-prolinamides with significant inhibitory activity against various human carcinoma cell lines .
2. 4-Fluoronitrobenzene serves as a crucial building block for preparing 3-chloro-4-fluoronitrobenzene and other agrochemical intermediates .
3. 4-Fluoronitrobenzene is utilized in medicinal chemistry research for developing hypobetalipoproteinemic agents and as a reagent for N-derivatization of histidine side chains .

1. Store 4-Fluoronitrobenzene CAS 350-46-9 in a tightly sealed container in a cool, dark place below 15°C, as 4-Fluoronitrobenzene is light sensitive and stable under inert atmosphere .
2. Keep 4-Fluoronitrobenzene strictly away from strong oxidizing agents, strong bases, and reducing agents due to incompatibility .
3. Handle 4-Fluoronitrobenzene using appropriate personal protective equipment including chemical-resistant gloves (butyl-rubber recommended), face shield, and in a fume hood to avoid breathing vapors or dust .

1. Isolate the spill area, eliminate all ignition sources, and contain liquid 4-Fluoronitrobenzene CAS 350-46-9 using dry inert absorbent material like sand, preventing entry into drains or waterways .
2. Collect absorbed 4-Fluoronitrobenzene using an electrically protected vacuum cleaner or non-sparking tools into sealed, labeled containers for disposal according to environmental regulations .
3. Personnel cleaning 4-Fluoronitrobenzene spills must wear full protective equipment including self-contained breathing apparatus, as vapors may accumulate to form explosive concentrations .

1. 4-Fluoronitrobenzene CAS 350-46-9 is toxic if swallowed and harmful if inhaled (LC50 rat: 2,600 mg/m³), with GHS signal word "Danger" .
2. 4-Fluoronitrobenzene causes skin and serious eye irritation (H315, H319), may cause an allergic skin reaction (H317), and has an NFPA health rating of 3 (serious hazard) .
3. 4-Fluoronitrobenzene has a flash point of 90°C, combustion produces toxic fumes including carbon oxides, nitrogen oxides, and hydrogen fluoride, and 4-Fluoronitrobenzene is classified for transport as a poison.