4-Nitrobenzenesulfonyl Chloride CAS 98-74-8

1. 4-Nitrobenzenesulfonyl chloride CAS 98-74-8 is widely used as a key reagent in the synthesis of sulfonamide-based pharmaceuticals, including drugs targeting bacterial infections, HIV (e.g., darunavir), and as an intermediate for various other drug candidates .
2. 4-Nitrobenzenesulfonyl chloride is an essential derivatizing agent in analytical chemistry, significantly enhancing the detection sensitivity of compounds like estrogens in biological fluids for LC-MS analysis .
3. 4-Nitrobenzenesulfonyl chloride serves as a versatile protecting and activating group for amines in organic synthesis, particularly in the Fukuyama alkylation for the selective monoalkylation of primary amines and in solid-phase peptide synthesis .

1. Store 4-Nitrobenzenesulfonyl chloride CAS 98-74-8 in a tightly sealed container in a cool, dry place (0-8 °C is recommended), as 4-Nitrobenzenesulfonyl chloride is moisture-sensitive and decomposes upon contact with water or moist air .
2. Keep 4-Nitrobenzenesulfonyl chloride strictly away from strong oxidizing agents, bases, and metals; 4-Nitrobenzenesulfonyl chloride is corrosive and may react violently, generating toxic and flammable gases .
3. Handle 4-Nitrobenzenesulfonyl chloride using appropriate personal protective equipment including splash-resistant safety goggles with a faceshield and chemical-resistant gloves, as 4-Nitrobenzenesulfonyl chloride causes severe skin, eye, and respiratory tract burns .

1. Isolate the spill area immediately, wear full protective equipment including a self-contained breathing apparatus, and do not touch the spilled material .
2. Contain solid 4-Nitrobenzenesulfonyl chloride using dry inert non-combustible material like sand, collect using non-sparking tools into sealed, labeled containers for disposal, and prevent entry into drains or waterways .
3. Personnel cleaning 4-Nitrobenzenesulfonyl chloride spills must keep unnecessary people away, isolate the hazard area, and dispose of waste according to hazardous material regulations .

1. 4-Nitrobenzenesulfonyl chloride CAS 98-74-8 is classified with GHS signal word "Danger" and is corrosive, causing severe skin burns, serious eye damage, and respiratory tract burns.
2. 4-Nitrobenzenesulfonyl chloride has an NFPA health rating of 3 (serious hazard); dust/air mixtures may ignite or explode, and 4-Nitrobenzenesulfonyl chloride may generate flammable and/or toxic gases upon contact with water or moist air .
3. 4-Nitrobenzenesulfonyl chloride is classified for transport as a corrosive solid (UN3261, Hazard Class 8, Packing Group II) and thermal decomposition produces toxic fumes including oxides of carbon, sulfur, nitrogen, and hydrogen chloride .