Benzyl Chloroformate CAS 501-53-1

Product name:Benzyl chloroformate

CAS:501-53-1

MF:C8H7ClO2

MW:170.59

EINECS:207-925-0

Density:1.212 g/ml

Melting point:-20°C

Boiling point:103°C

Packaging:1 L/bottle, 25 L/drum, 200 L/drum

Solubility:Dissolve in organic solvents such as ether, acetone and benzene.

Benzyl chloroformate is an organic compound mainly used in the field of organic synthesis, with specific applications as follows:
Amino protectant:
In antibiotic synthesis, Benzyl chloroformate is commonly used to protect the amino groups of amino acids, prevent side reactions or degradation in subsequent reactions, and thus improve synthesis efficiency. ‌
Pesticide and pharmaceutical intermediates:
Benzyl chloroformate, as a pesticide intermediate, participates in the key synthesis steps of pesticide molecules; In drug synthesis, benzyloxycarbonyl (CBZ) protecting groups can be introduced for the preparation of complex molecules such as antibiotics and anti-tumor drugs. ‌
Protein modification:
Benzyl chloroformate reacts with protein amino groups to form benzyl esters, which regulate the hydrophilicity and hydrophobicity of proteins, enhance their solubility and stability, and reduce aggregation phenomena. ‌
Nucleic acid modification:
Benzyl chloroformate can improve the stability and resistance to degradation of DNA/RNA, such as enhancing in vitro survival ability and regulating intermolecular binding properties. ‌
Esterification:
Benzyl chloroformate undergoes esterification reaction with alcohols, phenols, etc. to produce benzyl ether, which is commonly used in the synthesis of ester compounds under mild conditions. ‌