Diethyl Sulfate CAS 64-67-5

1. Diethyl sulfate is primarily used as a highly effective ethylating agent in organic synthesis to introduce ethyl groups into phenols, amines, and thiols for producing dyes, pigments, pharmaceuticals, and agricultural chemicals .
2. Diethyl sulfate CAS 64-67-5 serves as a key intermediate in the manufacturing of carbonless paper, textiles, and surfactants, and is utilized as a laboratory reagent and mutagen in genetic research, such as in the development of the Luther variety of barley .
3. Applications of Diethyl sulfate also include its use in the indirect hydration process for synthetic ethanol production and as an accelerator in certain sulfonation processes .

1. Store Diethyl sulfate in a tightly sealed container in a cool, dry, and well-ventilated place, protected from moisture and heat; recommended storage is in a cool, dark area below 15°C .
2. Keep Diethyl sulfate strictly away from strong oxidizing agents, strong bases, water, and foodstuffs; it reacts slowly with water to form corrosive sulfuric acid and is incompatible with materials like alkali metals .
3. Always Diethyl sulfate CAS 64-67-5 use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, and protective clothing; handle Diethyl sulfate only in a fume hood with explosion-proof equipment to avoid inhalation of vapors .

1. Immediately isolate the spill area (at least 50 meters), eliminate all ignition sources, and provide adequate ventilation; contain Diethyl sulfate using dry, inert, non-combustible absorbent material (e.g., dry sand) and DO NOT use water or combustible materials .
2. Carefully collect Diethyl sulfate CAS 64-67-5 using non-sparking tools into sealed, labeled corrosion-resistant chemical waste containers for proper disposal according to local, state, and federal environmental regulations; prevent entry into drains or waterways .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; Diethyl sulfate is classified for transport (UN1594, Hazard Class 6.1, PG II) .

1. Diethyl sulfate is classified as a GHS Category 1B carcinogen and Category 1B mutagen (H340/H350, Danger) and is corrosive, causing severe skin burns and serious eye damage (H314/H318); it is fatal if inhaled and harmful if swallowed or in contact with skin (H302+H312+H332) .
2. Diethyl sulfate has an NFPA health rating of 3 (serious hazard) and a flash point of 104°C (219°F); it is combustible and its thermal decomposition produces highly toxic fumes including sulfur oxides, and it hydrolyzes in the presence of moisture to form sulfuric acid and ethanol .
3. Diethyl sulfate CAS 64-67-5 is an IARC Group 2A (probably carcinogenic to humans) substance and is toxic to aquatic life with long-lasting effects (H402); always consult the specific Safety Data Sheet (SDS) for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338 for eyes, P301+P330+P331 for ingestion), and mandatory handling protocols .