Diphenylphosphine CAS 829-85-6

1. Diphenylphosphine CAS 829-85-6 is a fundamental building block for synthesizing a wide range of phosphine ligands (e.g., DPPE, DPPP) that are crucial in homogeneous transition metal catalysis for reactions like cross-coupling, hydroformylation, and hydrogenation .
2. Diphenylphosphine serves as a key intermediate for producing active ingredients in the pharmaceutical, agrochemical, and nutritional industries .
3. Diphenylphosphine is utilized in organic synthesis to prepare diphenylalkylphosphines and other phosphorus-containing compounds via alkylation and other reactions .

1. Store Diphenylphosphine CAS 829-85-6 in a tightly sealed container under an inert atmosphere in a cool, well-ventilated area, as it is pyrophoric and can ignite spontaneously in air .
2. Keep Diphenylphosphine strictly away from heat, sparks, open flames, and strong oxidizing agents; handle only with explosion-proof equipment in areas equipped for self-igniting materials .
3. Handle Diphenylphosphine using appropriate personal protective equipment, as it causes skin and eye irritation and may cause respiratory irritation.

1. Isolate the spill area immediately, evacuate personnel, and eliminate all ignition sources; wear full protective equipment including self-contained breathing apparatus, as Diphenylphosphine is spontaneously flammable .
2. Contain Diphenylphosphine by covering with dry inert material like sand, collect using non-sparking tools into sealed, labeled containers under inert atmosphere, and prevent entry into drains or waterways .
3. Personnel cleaning Diphenylphosphine spills must dispose of waste through a licensed chemical destruction facility, as it is a pyrophoric substance classified for transport.

1. Diphenylphosphine CAS 829-85-6 is classified with GHS signal word "Danger" as a pyrophoric liquid (H250, catches fire spontaneously if exposed to air) .
2. Diphenylphosphine causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) .
3. Diphenylphosphine has NFPA health, flammability, and reactivity ratings of 2, 4, and 2 respectively, has a flash point of 110-120°C, and its combustion produces toxic fumes including phosphorus oxides .