Ethoxymethylenemalononitrile CAS 123-06-8

1. Ethoxymethylenemalononitrile is a highly reactive, electron-deficient acrylonitrile derivative used as a versatile reagent in heterocyclic synthesis to produce fused pyrazoles, pyrimidines, and triazoles . It is widely employed in pharmaceutical research for synthesizing antimicrobial, anti-inflammatory, and antimalarial compounds .
2. Ethoxymethylenemalononitrile CAS 123-06-8 serves as a key building block in organic synthesis, particularly in condensation and cyclization reactions with nucleophiles like amines and hydrazines to create complex molecular frameworks .
3. Applications of Ethoxymethylenemalononitrile also include its use as an intermediate in the production of various pharmaceuticals and agrochemicals .

1. Store Ethoxymethylenemalononitrile in a tightly sealed container in a cool, dry, and well-ventilated area away from incompatible substances . Recommended storage temperatures vary from refrigeration (2-8°C) to -20°C for long-term stability .
2. Keep Ethoxymethylenemalononitrile away from strong oxidizing agents, strong reducing agents, strong acids, and strong bases to prevent hazardous decomposition reactions .
3. Always Ethoxymethylenemalononitrile CAS 123-06-8 use appropriate personal protective equipment (PPE) including chemical-resistant gloves (nitrile rubber recommended), safety goggles, and protective clothing when handling Ethoxymethylenemalononitrile to avoid skin, eye, and respiratory contact . Use only in a chemical fume hood .

1. Immediately isolate the spill area, avoid generating dusty conditions, and contain Ethoxymethylenemalononitrile using inert, non-combustible absorbent material . Prevent material from entering drains or waterways .
2. Carefully sweep up the collected Ethoxymethylenemalononitrile into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel Ethoxymethylenemalononitrile CAS 123-06-8 must wear suitable PPE including self-contained breathing apparatus (SCBA) if necessary during cleanup; provide adequate ventilation and dispose of all waste as hazardous material .

1. Ethoxymethylenemalononitrile is classified as toxic if swallowed (H301), harmful in contact with skin (H311), may cause an allergic skin reaction (H317), and may cause allergy or asthma symptoms or breathing difficulties if inhaled (H334) . LD50 intraperitoneal in mouse is 50 mg/kg .
2. Ethoxymethylenemalononitrile has a flash point of 155°C (311°F) and is combustible . Its thermal decomposition or combustion can produce toxic and irritating fumes, including nitrogen oxides (NOx), carbon monoxide, and carbon dioxide .
3. Always Ethoxymethylenemalononitrile CAS 123-06-8 consult the specific Safety Data Sheet (SDS) for Ethoxymethylenemalononitrile for complete hazard information (GHS signal word "Danger"), first-aid procedures (P301+P310 for ingestion, P302+P352 for skin, P304+P340 for inhalation), and handling instructions; precautionary statements include P260 (do not breathe dust), P280 (wear protective gloves/eye protection), and P342+P311 (if experiencing respiratory symptoms) .