Hexamethonium Chloride CAS 60-25-3

1. Serves as a ganglionic nicotinic receptor blocker in neuropharmacological research to study autonomic nervous system signal transmission.
2. Acts  Hexamethonium chloride as a tool compound for investigating the role of nicotinic receptors in cardiovascular and gastrointestinal physiological processes.
3. Functions as a reference standard in pharmaceutical analysis for validating analytical methods targeting quaternary ammonium - based ganglionic blockers.
4. Hexamethonium chloride is used in preclinical studies to explore potential treatments for conditions related to abnormal autonomic ganglionic activity, such as certain hypertensive models.

1. Store in airtight glass or HDPE containers at 15–25℃ in a cool, dry, well - ventilated area to prevent moisture absorption (hygroscopic).
2. Keep Hexamethonium chloride away from strong oxidizers, strong acids and alkalis to avoid chemical decomposition and unwanted reactions.
3. Wear nitrile gloves, safety goggles and a dust respirator during handling to prevent skin contact, eye irritation and dust inhalation.
4. Avoid Hexamethonium chloride ingestion and direct inhalation of dust; dispose of waste and contaminated materials through licensed hazardous waste disposal services.

1. High Hexamethonium chloride CAS 60-25-3 selectivity for ganglionic nicotinic receptors enables precise blocking of autonomic ganglionic transmission in research settings.
2. Water - soluble nature allows easy formulation into aqueous solutions for in vitro and in vivo experimental applications.
3. Well - characterized Hexamethonium chloride pharmacological profile makes it a reliable positive control for validating new ganglionic blocker candidates.
4. Stable under recommended storage conditions, ensuring consistent performance over long - term research use.

Hexamethonium chloride is classified as a harmful solid (H302, harmful if swallowed), skin irritant (H315, causes skin irritation) and serious eye irritant (H318, causes serious eye damage). Hexamethonium chloride may cause respiratory tract irritation if inhaled as dust. There is limited data on its environmental toxicity, but it should not be released into waterways. Its UN transport number is UN 3261 (Packing Group III). It is for research use only and not intended for human or veterinary therapeutic applications.