Isovanillin CAS 621-59-0

1. Isovanillin is primarily used as a key intermediate in organic synthesis, notably as a precursor in the chemical total synthesis of morphine . It is also widely employed as a pharmaceutical intermediate .
2. Isovanillin CAS 621-59-0 serves as a potent and reversible inhibitor of aldehyde oxidase (AO), with a Ki value of 0.664 μM . It has been investigated for various biological roles, including antifungal, antispasmodic, and antidiarrheal activities .
3. Applications of Isovanillin also include its use in the food and beverage industry, in the creation of synthetic fragrances, and as a reagent in biochemical research .

1. Store Isovanillin in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light and heat . Recommended storage temperatures vary: powder forms can be stored at -20°C for 3 years or 4°C for 2 years; solutions in solvent are best kept at -80°C for 6 months or -20°C for 1 month . For regular lab use, a cool, dark place below 15°C is generally advised .
2. Keep Isovanillin away from strong oxidizing agents and strong bases, as it is incompatible with these materials . It is also sensitive to light, air, and prolonged exposure to the atmosphere, which can degrade its purity .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves (e.g., nitrile), safety goggles with side shields or a face shield, and protective clothing when handling Isovanillin to avoid dust generation and contact with skin, eyes, or clothing . Use only with adequate ventilation or in a fume hood.

1. Immediately isolate the spill area, avoid dust formation, and ensure adequate ventilation. Contain Isovanillin using inert, non-combustible absorbent material (e.g., diatomaceous earth, universal binder) and prevent entry into drains or waterways .
2. Carefully sweep up the spilled Isovanillin solid using clean, non-sparking tools or use an explosion-proof vacuum. For residues, use alcohol to scrub surfaces and equipment. Place all collected material and contaminated items into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must Isovanillin CAS 621-59-0 wear suitable PPE, including chemical-resistant gloves and protective clothing, during cleanup . Isovanillin is not regulated as a hazardous material for transport by some classifications .

1. Isovanillin is classified as a warning signal word substance under GHS. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . Reported acute toxicity includes an intraperitoneal LD50 of 1,276 mg/kg in rats .
2. Isovanillin is combustible with a flash point of 179°C . Its thermal decomposition or combustion produces toxic and irritating fumes, including carbon oxides . Isovanillin CAS 621-59-0 is stable under recommended storage conditions but should be protected from strong oxidizing agents .
3. Always consult the specific Safety Data Sheet (SDS) for Isovanillin for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin, P304+P340 for inhalation), and handling instructions. Precautionary statements include P261 (avoid breathing dust), P264 (wash skin thoroughly after handling), P280 (wear protective gloves/eye protection), and P337+P313 (if eye irritation persists, get medical advice) .