Thiolacetic Acid CAS 507-09-5

1. Thiolacetic acid is primarily used as a versatile reagent in organic synthesis, acting as an acylating agent to convert alcohols into thiolacetate esters and as a nucleophile in Michael addition reactions with α,β-unsaturated carbonyl compounds .
2. Thiolacetic acid CAS 507-09-5 serves as a key intermediate for preparing pharmaceuticals (e.g., the antifungal drug sulconazole), biochemical reagents, and is used in the production of pesticides, polymers, and modifiers .
3. Applications of Thiolacetic acid also include its use as a metal precipitating agent in analytical chemistry and as a synthetic intermediate for sulfur-containing compounds like thioctic acid and mercaptocarboxylic acids .

1. Store Thiolacetic acid in a tightly sealed container under an inert atmosphere in a cool, dry, well-ventilated area away from heat, sparks, and open flames; long-term storage at 2-8°C under nitrogen is recommended .
2. Keep Thiolacetic acid strictly away from strong oxidizing agents, strong bases, and moisture due to its reactivity and potential to form explosive mixtures with air .
3. Always use Thiolacetic acid CAS 507-09-5 appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, face shield, and flame-retardant antistatic clothing; handle only in a fume hood with explosion-proof equipment .

1. Immediately isolate the spill area (minimum 50 meters), eliminate all ignition sources, and ensure adequate ventilation; contain Thiolacetic acid using dry, inert, non-combustible absorbent material (dry sand or earth) and DO NOT use combustible materials like sawdust .
2. Carefully collect Thiolacetic acid CAS 507-09-5 using non-sparking tools or an explosion-proof vacuum into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; Thiolacetic acid is classified for transport (UN2436, Hazard Class 3, PG II) and may also be assigned UN2936 (Hazard Class 6.1) depending on specific hazards .

1. Thiolacetic acid is classified as a highly flammable liquid and vapor (H225) with a flash point ranging from -10°C to 18°C; it is corrosive causing severe skin burns and serious eye damage (H314/H318) and is toxic if swallowed, inhaled, or in contact with skin (H301+H311+H332) .
2. Thiolacetic acid has an acute oral LD50 of 200-350 mg/kg in rats; its vapors are heavier than air (vapor density 2.6) and may form explosive mixtures, while thermal decomposition produces toxic fumes including sulfur oxides and carbon oxides .
3. Always consult Thiolacetic acid CAS 507-09-5 the specific Safety Data Sheet (SDS) for Thiolacetic acid for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338 for eyes, P301+P310 for ingestion), and mandatory handling protocols; NFPA health rating is 3 (serious hazard), fire rating is 3, and reactivity rating is 0 .