Tributylphosphine CAS 998-40-3

1. Tributylphosphine CAS 998-40-3 is widely used as a ligand in transition metal complexes for homogeneous catalysis, including olefin polymerization and hydroformylation reactions .  Tributylphosphine serves as an uncharged reducing agent for cleaving disulfide bonds in proteins, particularly in proteomics research for sample preparation prior to electrophoresis .
2. The compound functions as a versatile catalyst in organic synthesis, including 1,4-addition reactions, acylation, thioetherification of alcohols with disulfides, and preparation of active esters .Tributylphosphine is also used in the nuclear industry as a metal extractant for uranium and plutonium .
3. Applications of Tributylphosphine extend to its use as a flame retardant additive in plastics and coatings, a phase transfer catalyst intermediate, and a polymerization cross-linking catalyst .

1. Store Tributylphosphine CAS 998-40-3 in a tightly sealed container under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated place, protected from light and moisture . Storage at room temperature in a cool, dark place is acceptable for pure material, though some solutions require refrigeration .
2. Keep Tributylphosphine strictly away from air, moisture, strong oxidizing agents, acids, and halogens due to its pyrophoric nature and reactivity . Tributylphosphine may ignite spontaneously on contact with air and reacts vigorously with oxidizers.
3. Always Tributylphosphine use appropriate personal protective equipment (PPE) including chemical-resistant gloves (nitrile/neoprene), tightly fitting safety goggles, face shield, and flame-retardant antistatic protective clothing . Handle Tributylphosphine only in a fume hood with inert atmosphere and use spark-proof, explosion-proof equipment.

1. Immediately isolate the spill area (at least 50 meters), evacuate all personnel, and eliminate all ignition sources. DO NOT use combustible materials like paper towels for cleanup . Absolutely avoid contact with air and water.
2. Contain Tributylphosphine using dry, inert, non-combustible absorbent material (dry sand, vermiculite) under inert atmosphere if possible. Carefully collect the contaminated material using non-sparking tools into a sealed, corrosion-resistant chemical waste container purged with inert gas .
3. Personnel Tributylphosphine must wear full chemical-protective equipment including positive pressure self-contained breathing apparatus (SCBA) during cleanup . Prevent entry into drains or waterways and dispose of all waste according to hazardous material regulations. Tributylphosphine is classified for transport.

1. Tributylphosphine CAS 998-40-3 is classified as a pyrophoric liquid (H250, Danger) that catches fire spontaneously if exposed to air, and is corrosive causing severe skin burns and serious eye damage (H314/H318) . It is flammable with flash points reported from 58°C to 106°C depending on conditions .
2. Tributylphosphine is harmful if swallowed (H302), in contact with skin (H312), and may cause respiratory irritation (H335) . It has an acute oral LD50 of approximately 750-820 mg/kg in rats . Thermal decomposition produces highly toxic fumes including phosphine and oxides of phosphorus .
3. Tributylphosphine is toxic to aquatic life with long-lasting effects (H411) . It has an unpleasant odor and requires handling under inert atmosphere to prevent oxidation to tributylphosphine oxide . Always consult the specific Safety Data Sheet (SDS) for Tributylphosphine for complete hazard information, first-aid procedures, and mandatory handling protocols .