2-Chloroquinoline CAS 612-62-4

1. 2-Chloroquinoline CAS 612-62-4 is a key intermediate in organic synthesis for producing pharmaceuticals, agrochemicals, and dyestuffs, and possesses antimicrobial activity against bacterial and fungal strains .
2. 2-Chloroquinoline reacts with benzotriazole to form the indolo[2,3-b]quinoline ring system, a scaffold for novel cytotoxic DNA topoisomerase II inhibitors .
3. 2-Chloroquinoline is pivotal for nucleophilic substitution and cross-coupling reactions like Suzuki and Heck, essential for creating advanced organic molecules for materials science and catalysis .

1. Store 2-Chloroquinoline CAS 612-62-4 in a tightly sealed container in a cool, dry, well-ventilated place, as it is air and heat sensitive . Recommended storage is at room temperature or refrigerated (0-10°C) under inert gas .
2. Keep 2-Chloroquinoline away from strong oxidizing agents and ensure the container is kept tightly closed .
3. Handle 2-Chloroquinoline using appropriate personal protective equipment including gloves and eye/face protection, as it causes skin and serious eye irritation.

1. Isolate the spill area, avoid dust formation, and wear full protective equipment including a suitable respirator .
2. Sweep up solid 2-Chloroquinoline using non-sparking tools into sealed, labeled containers for disposal, and prevent entry into drains or waterways .
3. Personnel cleaning 2-Chloroquinoline spills must dispose of waste according to environmental regulations, as 2-Chloroquinoline is harmful to aquatic life with long-lasting effects .

1. 2-Chloroquinoline CAS 612-62-4 is classified with GHS signal word "Warning" and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation.
2. 2-Chloroquinoline has a flash point >110°C, is insoluble in water, and has a melting point of 34-37°C .
3. Thermal decomposition of 2-Chloroquinoline produces toxic fumes including carbon monoxide, carbon dioxide, and hydrogen chloride; the compound is stable under normal temperatures and pressures when stored properly .