2-Methoxy-5-fluorouraci CAS 1480-96-2

1. 2-Methoxy-5-fluorouracil is a fluorinated pyrimidine derivative primarily used as a pharmaceutical intermediate and reference standard in the development of anticancer agents, where its structural similarity to nucleobases enables it to interfere with DNA and RNA synthesis in rapidly dividing cells .
2. 2-Methoxy-5-fluorouraci CAS 1480-96-2 serves as a key impurity reference standard (Fluorouracil EP Impurity) for analytical method development and quality control during the commercial production of fluorouracil-based therapeutics .
3. As an antimetabolite, 2-Methoxy-5-fluorouracil is studied for its ability to inhibit thymidylate synthase, leading to depletion of deoxythymidine triphosphate (dTTP) and disruption of DNA replication in cancer cells .
4. Researchers utilize 2-Methoxy-5-fluorouraci CAS 1480-96-2 as a versatile building block in medicinal chemistry for the synthesis of novel pyrimidine-based drug candidates with potential applications in oncology and other therapeutic areas .

1. 2-Methoxy-5-fluorouracil must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; long-term storage at 2-8°C (refrigerated) is recommended .
2. 2-Methoxy-5-fluorouraci CAS 1480-96-2 is classified as an irritant with GHS hazard statements R36/37/38 (Irritating to eyes, respiratory system, and skin), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep 2-Methoxy-5-fluorouraci CAS 1480-96-2 away from incompatible materials such as strong oxidizing agents to prevent decomposition; the compound has a WGK Germany 3 classification (high water hazard potential) and should not be released into the environment .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 2-Methoxy-5-fluorouracil is released .
2. Collect 2-Methoxy-5-fluorouraci CAS 1480-96-2 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 2-Methoxy-5-fluorouracil is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen fluoride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 2-Methoxy-5-fluorouraci CAS 1480-96-2 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-Methoxy-5-fluorouracil due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .