2-Acetyl-5-bromothiophene CAS 5370-25-2

1. 2-Acetyl-5-bromothiophene CAS 5370-25-2 is primarily used as a versatile building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals, and as a starting reagent for synthesizing bithiophene bis-imidazo[1,2-a]pyridine derivatives .
2. 2-Acetyl-5-bromothiophene is employed in material science for creating functional materials such as conducting polymers and organic light-emitting diodes (OLEDs), enhancing the performance of electronic devices .
3. 2-Acetyl-5-bromothiophene is utilized in biological research to study its potential antibacterial and antifungal properties, where derivatives have demonstrated significant activity against multidrug-resistant strains of *Salmonella Typhi* with minimum inhibitory concentration (MIC) values as low as 3.125 mg/mL .
4. Researchers employ 2-Acetyl-5-bromothiophene in medicinal chemistry for drug development, including the preparation of phosphorus-containing fused bicyclic compounds, and as a standard reference material in analytical chemistry for instrument calibration .

1. 2-Acetyl-5-bromothiophene CAS 5370-25-2 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 0-8°C, protected from light as it is light sensitive .
2. 2-Acetyl-5-bromothiophene is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), and H302+H312+H332 (Harmful if swallowed, in contact with skin or if inhaled), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, face protection, and protective clothing when handling this substance, ensuring adequate ventilation in work areas (preferably a chemical fume hood) and avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents; wash thoroughly after handling; the compound has WGK Germany 3 (high water hazard potential) .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 2-acetyl-5-bromothiophene CAS 5370-25-2 is released, evacuating non-essential personnel .
2. Collect 2-Acetyl-5-bromothiophene by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided due to potential environmental hazards .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with flue gas scrubbing, noting UN2811 classification for toxic solids .

1. 2-Acetyl-5-bromothiophene CAS 5370-25-2 is combustible with a flash point of approximately 123.3°C, melting point of 91-98°C, and boiling point of 103°C at 4 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen bromide .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use a direct water jet as 2-Acetyl-5-bromothiophene may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-acetyl-5-bromothiophene due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .