4-Hydroxy-L-phenylglycine CAS 32462-30-9

1. As a key chiral intermediate for β-lactam antibiotics, it is widely used in the synthesis of semi-synthetic penicillins and cephalosporins such as amoxicillin, cefalexin, and cefradine. It is the core raw material for achieving the optical purity of such antibiotics, ensuring the antibacterial activity and targeting of the drugs.
2. 4-Hydroxy-L-phenylglycine CAS 32462-30-9 is used in the preparation of peptide drugs, cardiovascular disease treatment drugs and antiviral drugs. It can be used as a chiral structural unit to regulate the spatial conformation of drug molecules, improve the bioavailability and efficacy of drugs, and reduce side effects.
3. 4-Hydroxy-L-phenylglycine CAS 32462-30-9 is applied in the field of asymmetric synthesis as a chiral inducer to assist the synthesis of various chiral compounds. At the same time, it can also be used as a substrate for biocatalytic reactions, providing core support for drug research and development and fine chemical production.

1. Store in a cool, dry, well-ventilated warehouse with an ambient temperature controlled at 0-25℃. Avoid high temperatures (oxidative deterioration is likely to occur above 30℃) and humid environments to prevent the product from absorbing moisture, caking and reducing activity.
2. Store 4-Hydroxy-L-phenylglycine CAS 32462-30-9 in a sealed manner, use special sealed containers (such as brown glass bottles, HDPE plastic bottles) to isolate air, moisture and dust. Avoid mixing with strong oxidants, strong acids, strong alkalis and other corrosive substances to prevent chemical reactions leading to product deterioration.
3. Operation must be carried out in a fume hood. Wear disposable gloves, goggles and lab coats to avoid direct contact with skin and mucous membranes. Wash hands thoroughly after operation to prevent irritation from residual reagents.

1. 4-Hydroxy-L-phenylglycine CAS 32462-30-9 has mild irritation. Contact with skin will cause mild redness, swelling and itching, and contact with eyes may cause stinging and tearing. Sensitive people may have mild allergic reactions.
2. Inhalation of its dust is prohibited, and accidental ingestion should be avoided. If accidentally inhaled or ingested, immediately leave the scene, inhale fresh air, and those who take 4-Hydroxy-L-phenylglycine by mistake should seek medical attention in time and must not induce vomiting by themselves.
3. During operation, 4-Hydroxy-L-phenylglycine CAS 32462-30-9 is necessary to strictly control the diffusion of dust. Clean the operation table in time after the experiment. Waste reagents should be classified and disposed of in accordance with the handling specifications of hazardous chemicals, and must not be discarded at will.

1. High optical purity (ee value ≥ 99%) and stable chiral structure, which can accurately meet the strict requirements of drug synthesis for stereoconfiguration, effectively avoid side effects caused by racemates, and improve drug quality.
2. Excellent solubility, with good solubility in common polar solvents such as water, methanol and ethanol. 4-Hydroxy-L-phenylglycine CAS 32462-30-9 is suitable for various reaction systems, without complex solubilization treatment, simplifying the synthesis process.
3. Strong chemical stability, not easy to decompose under conventional reaction conditions (such as mild acid-base, normal temperature and pressure), can withstand multiple synthetic reaction steps, reduce losses in the production process, and improve reaction yield.