5-Amino-2-chloropyridine CAS 5350-93-6

1. 5-Amino-2-chloropyridine is primarily used as a key intermediate in the synthesis of pharmaceuticals, including quinolone antibiotics and antiulcer agents like pirenzepine, and for the preparation of [2H5]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine, a potential therapeutic agent .
2. 5-Amino-2-chloropyridine CAS 5350-93-6 serves as a versatile building block in organic synthesis, undergoing reactions such as Suzuki-Miyaura coupling with sterically hindered boronic acids and temperature-dependent displacement of chloride by bromide via the Sandmeyer reaction to yield 2,5-dibromopyridine .
3. 5-Amino-2-chloropyridine is employed in agrochemical research for synthesizing pesticides and herbicides, and in the production of the plant growth regulator KT-30 (Forchlorfenuron), which enhances fruit yield and quality .
4. Researchers utilize 5-Amino-2-chloropyridine CAS 5350-93-6 for identifying and evaluating molecularly imprinted polymers designed for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceutical compounds .

1. 5-Amino-2-chloropyridine must be stored in a tightly sealed container under inert gas (nitrogen or argon) in a cool, dry, and well-ventilated environment, protected from light and air as 5-Amino-2-chloropyridine CAS 5350-93-6 is light and air sensitive .
2. Recommended storage is at room temperature in a cool, dark place below 15°C, with the compound stable under these conditions when stored properly .
3. 5-Amino-2-chloropyridine CAS 5350-93-6 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), and H302+H312+H332 (Harmful if swallowed, in contact with skin or if inhaled), with signal word "Warning" .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, eliminate all ignition sources, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95) when 5-amino-2-chloropyridine is released .
2. Collect 5-Amino-2-chloropyridine CAS 5350-93-6 by sweeping or vacuuming without creating dust using non-sparking tools, or cover with dry earth, sand or other non-combustible material, and place into suitable closed containers for disposal, taking care not to get water inside containers .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces using appropriate methods; prevent the product from entering drains or water courses as 5-Amino-2-chloropyridine CAS 5350-93-6 is harmful to aquatic life (WGK Germany 3) .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations, noting UN2811 classification for toxic solids .

1. 5-Amino-2-chloropyridine is combustible with a flash point of 130.7°C; the substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride .
2. Use 5-Amino-2-chloropyridine CAS 5350-93-6 dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray appropriate for surrounding fire to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-amino-2-chloropyridine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .