2-(Trimethylsilyl)pyridine CAS 13737-04-7

1. 2-(Trimethylsilyl)pyridine CAS 13737-04-7 is primarily used as a versatile building block in synthetic chemistry, where its reactive silicon-carbon bond adjacent to the pyridine nitrogen enables selective cleavage and functionalization for constructing complex molecules .
2. 2-(Trimethylsilyl)pyridine is employed in supramolecular chemistry to synthesize ligands such as 2,2'-bipyridines and terpyridines, which are crucial for constructing molecular architectures with applications in molecular recognition and self-assembly processes .
3. 2-(Trimethylsilyl)pyridine is utilized in organic synthesis to create heterocyclic ketones, keto-acids, esters, and alcohols through silicon-carbon bond cleavage, and serves as a nucleophile in cross-coupling reactions such as the Heck reaction for forming new carbon-carbon bonds .
4. Researchers employ 2-(Trimethylsilyl)pyridine in organometallic chemistry to synthesize cyclopalladated complexes with dynamic behavior relevant to catalysis, and in nucleophilic addition reactions with carbonyl compounds to generate various alcohols .

1. 2-(Trimethylsilyl)pyridine CAS 13737-04-7 must be stored in a tightly sealed container under inert atmosphere (nitrogen or argon) in a cool, dry, and well-ventilated environment, preferably in a cool and dark place below 15°C as it is air and light sensitive .
2. 2-(Trimethylsilyl)pyridine is classified as a combustible liquid with flash point ranging from 52-64°C, and GHS hazard statements include H315 (Causes skin irritation), H319 (Causes serious eye irritation), H227 (Combustible liquid), and risk phrases R10 (Flammable) and R36/37/38 (Irritating to eyes, respiratory system, and skin) .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of vapors or mists .
4. Keep 2-(Trimethylsilyl)pyridine away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents; wash thoroughly after handling and follow precautionary statements P210, P264, P280, and P305+P351+P338 .

1. Isolate the spill area immediately, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and appropriate respiratory protection when 2-(Trimethylsilyl)pyridine is released .
2. Collect 2-(Trimethylsilyl)pyridine using non-sparking tools by absorbing with inert materials such as sand, diatomite, or universal binders, and place into suitable closed containers for disposal; for small spills, a vapor-suppressing foam may be used to reduce vapors .
3. Avoid creating vapors or mists during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided (WGK Germany 3 - high water hazard potential) .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations, noting UN1993 (Flammable Liquid) or UN1993 with packing group III for transport classification .

1. 2-(Trimethylsilyl)pyridine CAS 13737-04-7 is a combustible liquid with flash point 52-64°C and NFPA fire rating of 2; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use 2-(Trimethylsilyl)pyridine dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as it may scatter burning material and spread the fire .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-(Trimethylsilyl)pyridine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .