5-Bromouracil CAS 51-20-7

1. 5-Bromouracil is a halogenated pyrimidine analog used as a thymine antimetabolite in biochemical and genetic research, where it induces base substitution mutations by incorporating into DNA in place of thymine and mispairing with guanine .
2. 5-Bromouracil CAS 51-20-7 serves as a mutagen and density label for nucleic acids in studies of DNA replication, repair, and recombination, and is widely employed in the analysis of chromosome structure and function .
3. 5-Bromouracil is utilized as a pharmaceutical intermediate in the synthesis of antiviral, antimicrobial, and antitumor agents, and has been studied for its potential in cancer photodynamic therapy (PDT) .
4. Researchers employ 5-Bromouracil CAS 51-20-7 in cell biology for BrdU (5-bromo-2'-deoxyuridine) labeling to detect proliferating cells and analyze cell cycle kinetics in tissues .

1. 5-Bromouracil must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 2-8°C (refrigerated), protected from light and moisture .
2. For long-term stability, storage at -20°C is recommended; solutions should be stored at -20°C for up to 1 month, avoiding repeated freeze-thaw cycles .
3. 5-Bromouracil CAS 51-20-7 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), H302 (Harmful if swallowed), and H312 (Harmful in contact with skin), with signal word "Warning" .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 5-Bromouracil is released .
2. Collect 5-Bromouracil CAS 51-20-7 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 5-Bromouracil is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen bromide .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 5-Bromouracil CAS 51-20-7 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-Bromouracil due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .