Methyl Indole-5-carboxylate CAS 1011-65-0

Methyl indole-5-carboxylate (CAS:1011-65-0) is an important Indole compounds.

Its main applications including:

1. Methyl indole-5-carboxylate is an essential indole intermediate for the synthesis of anti-tumor drugs and central nervous system related pharmaceutical molecules.
2. Methyl indole-5-carboxylate is a common reaction substrate for Suzuki coupling and multi-step heterocyclic structural construction in fine organic synthesis.
3. Methyl indole-5-carboxylate is a synthetic precursor for biological fluorescent probes and nitrogen-containing organic optoelectronic functional materials.

1. Seal the container tightly and store at temperature below 25 °C in a dry dark environment to prevent photolysis of the indole ring.
2. Reduce frequent opening of the package to prevent oxidative discoloration induced by long-term exposure to air.
3. Isolate storage space from strong acids, strong alkalis and oxidants to avoid hydrolysis of the methyl ester group.

1. Prevent inhalation of crystalline dust; wear dust-proof masks and chemical resistant gloves during weighing and transferring operations.
2. Oral intake is forbidden. Immediately wash the contacted skin and eyes with a large amount of running water once accidental contact happens.
3. Waste solids and filtrate shall be treated in accordance with the disposal standards of nitrogen-containing aromatic ester hazardous waste.
 

1. The methyl ester group can be hydrolyzed into carboxyl groups to carry out amidation, condensation and other derivatization reactions.
2. The complete indole heterocyclic skeleton keeps stable under conventional heating and catalytic reaction conditions.
3. High-purity crystal raw materials can effectively reduce impurity by-products in the preparation of bioactive intermediates.