5-Chlorouracil CAS 1820-81-1

1. 5-Chlorouracil is a halogenated pyrimidine analog used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of antiviral and anticancer agents targeting pyrimidine metabolism .
2. 5-Chlorouracil CAS 1820-81-1 serves as a versatile building block in organic synthesis for the preparation of substituted uracil derivatives, where the chlorine atom enables selective nucleophilic substitution reactions .
3. 5-Chlorouracil is employed in biochemical research to study enzyme inhibition mechanisms, particularly thymidylate synthase and other enzymes involved in nucleotide metabolism .
4. Researchers utilize 5-Chlorouracil CAS 1820-81-1 as a reference standard in analytical chemistry and as a starting material for the preparation of various heterocyclic compounds with potential biological activities .

1. 5-Chlorouracil must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. 5-Chlorouracil CAS 1820-81-1 is classified with GHS hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 5-Chlorouracil is released .
2. Collect 5-Chlorouracil CAS 1820-81-1 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 5-Chlorouracil is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 5-Chlorouracil CAS 1820-81-1 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-Chlorouracil due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .