5-Fluorouracil CAS 51-21-8

1. 5-Fluorouracil is a pyrimidine analog antimetabolite primarily used as a potent antitumor agent for the treatment of breast, colon, rectal, gastric, and pancreatic cancers .
2. 5-Fluorouracil CAS 51-21-8 functions by inhibiting thymidylate synthase, which depletes intracellular dTTP pools and disrupts DNA synthesis; 5-Fluorouracil is also metabolized to ribonucleotides and deoxyribonucleotides that incorporate into RNA and DNA, inducing apoptosis .
3. 5-Fluorouracil is employed in research applications including quorum sensing studies, biofilm inhibition, and as a reagent for inducing gastropathy (gastric mucosal injury) and nausea/vomiting in preclinical models .
4. In pharmaceutical development, 5-Fluorouracil CAS 51-21-8 serves as the parent compound for several prodrugs, including capecitabine, doxifluridine, tegafur, and S-1 (tegafur combined with gimeracil and potassium oxonate) .

1. 5-Fluorouracil CAS 51-21-8 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light, with recommended storage at room temperature in a cool, dark place below 15°C .
2. 5-Fluorouracil is stable for up to 3 years at -20°C or 2 years at 4°C when stored as powder; solutions should be stored at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles .
3. 5-Fluorouracil CAS 51-21-8 is classified with GHS signal word "Danger" and hazard statements H301 (Toxic if swallowed), H315 (Causes skin irritation), and H319 (Causes serious eye irritation); it is a hazardous drug requiring handling only by trained personnel .
4. Keep 5-Fluorouracil away from incompatible materials such as strong oxidizing agents and strong bases; it has a WGK Germany 3 classification (high water hazard potential) and should not be released into the environment .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant rubber gloves, safety goggles, and NIOSH/MSHA-approved respirator when 5-Fluorouracil is released .
2. Collect 5-Fluorouracil CAS 51-21-8 by sweeping or vacuuming without creating dust using non-sparking tools; for solutions, absorb with inert materials such as diatomite or universal binders .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol, and prevent 5-Fluorouracil from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; 5-Fluorouracil is classified under UN2811 (Toxic solid, organic, n.o.s.) with packing group III for transport .

1. 5-Fluorouracil is not classified as highly flammable but is a combustible solid that may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving 5-Fluorouracil; do NOT use a direct water jet as 5-Fluorouracil CAS 51-21-8 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-Fluorouracil due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, 5-Fluorouracil may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .