Indole-5-carboxylic Acid CAS 1670-81-1

1. Indole-5-carboxylic acid is widely utilized as a key intermediate in pharmaceutical synthesis, particularly in the development of anti-inflammatory and analgesic drugs, as well as potential anticancer immunomodulators like tryptophan dioxygenase inhibitors .
2. TIndole-5-carboxylic acid CAS 1670-81-1 is employed in biochemical research to study enzyme inhibition, protein interactions, and metabolic pathways, including its use as a reactant for synthesizing indirubin derivatives and Hedgehog pathway inhibitors .
3. Indole-5-carboxylic acid is used in materials science for the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films, and in the production of advanced polymers, nanomaterials, and fluorescent materials for electronics and coatings applications .
4. Researchers utilize Indole-5-carboxylic acid CAS 1670-81-1 in agricultural chemistry for developing herbicides, insecticides, and plant growth regulators, as well as in natural product synthesis for creating alkaloids and other biologically active compounds derived from natural sources .

1. Indole-5-carboxylic acid must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage temperatures range from 0-8°C (refrigerator) to room temperature in a cool, dark place below 15°C, with long-term storage at -20°C for maximum stability .
2. Indole-5-carboxylic acid CAS 1670-81-1 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning"; it is also harmful if swallowed (H302) and may cause allergic skin reaction according to some sources .
3. Personnel must wear chemical-resistant gloves, tightly fitting safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols, and ensuring adequate ventilation in work areas (preferably a chemical fume hood) .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent decomposition; wash thoroughly after handling; the compound is soluble in ethanol (50 mg/mL), DMSO, and methanol, and should be kept away from strong acids or bases .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Indole-5-carboxylic acid is released, evacuating non-essential personnel .
2. Collect Indole-5-carboxylic acid CAS 1670-81-1 by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces using appropriate methods; prevent the product from entering drains or water courses as it is slightly harmful to aquatic life with long-lasting effects .
4. Dispose of collected Indole-5-carboxylic acid CAS 1670-81-1 material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration, as the substance is not classified as dangerous for transport but requires proper waste management .

1. Indole-5-carboxylic acid is combustible with a flash point of approximately 207.6°C and boiling point of 419.6°C at 760 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use a direct water jet as Indole-5-carboxylic acid CAS 1670-81-1 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Indole-5-carboxylic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .