What is the solubility of the chemical with CAS 141-82-2 in organic solvents?

What is the solubility of the chemical with CAS 141-82-2 in organic solvents?

As a reliable supplier of the chemical with CAS 141-82-2, I often receive inquiries regarding its solubility in various organic solvents. Understanding the solubility of this chemical is crucial for its numerous applications across different industries, such as pharmaceuticals, agrochemicals, and materials science. In this blog post, I'll delve into the solubility characteristics of the chemical with CAS 141-82-2 in organic solvents, providing valuable insights for those interested in its use.

Chemical Background

The chemical with CAS 141-82-2 is malonic acid, a dicarboxylic acid with the molecular formula C₃H₄O₄. It is a white crystalline solid that is soluble in water and has a wide range of industrial applications. Malonic acid is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals, dyes, and polymers.

Solubility in Organic Solvents

The solubility of malonic acid in organic solvents depends on several factors, including the nature of the solvent, temperature, and the presence of other solutes. Generally, malonic acid is more soluble in polar organic solvents due to its polar carboxylic acid groups.

1. Alcohols
   Malonic acid exhibits good solubility in alcohols such as methanol, ethanol, and propanol. The hydroxyl group in alcohols can form hydrogen bonds with the carboxylic acid groups of malonic acid, enhancing its solubility. For example, at room temperature, malonic acid is highly soluble in methanol, with a solubility of approximately 100 g/100 mL. In ethanol, the solubility is slightly lower, around 60 g/100 mL. As the carbon chain length of the alcohol increases, the solubility of malonic acid decreases due to the increasing non - polar nature of the alcohol.

2. Ethers
   In ethers like diethyl ether and tetrahydrofuran (THF), malonic acid has limited solubility. Ethers are relatively non - polar solvents, and their ability to form hydrogen bonds with malonic acid is weaker compared to alcohols. Diethyl ether has a low solubility for malonic acid, typically less than 1 g/100 mL at room temperature. THF, being a more polar ether, can dissolve a slightly higher amount of malonic acid, but still, the solubility is not as high as in alcohols.

   

3. Ketones
   Acetone is a common ketone solvent, and malonic acid has moderate solubility in it. The carbonyl group in acetone can interact with the carboxylic acid groups of malonic acid through dipole - dipole interactions. At room temperature, the solubility of malonic acid in acetone is around 10 - 15 g/100 mL.

4. Aromatic Solvents
   In aromatic solvents such as benzene and toluene, malonic acid has very low solubility. These solvents are non - polar and do not have the ability to form strong interactions with the polar malonic acid molecules. The solubility of malonic acid in benzene and toluene is less than 0.1 g/100 mL at room temperature.

Temperature Dependence of Solubility

The solubility of malonic acid in organic solvents generally increases with increasing temperature. As the temperature rises, the kinetic energy of the molecules increases, allowing for more effective breaking of intermolecular forces and better solvation of the malonic acid molecules. For example, in ethanol, the solubility of malonic acid can increase significantly from 60 g/100 mL at room temperature to over 100 g/100 mL at higher temperatures (e.g., 60 - 70 °C).

Importance of Solubility in Applications

The solubility of malonic acid in organic solvents is of great importance in its various applications. In organic synthesis, the solubility determines the choice of solvent for a particular reaction. For example, if a reaction requires malonic acid to be in solution for efficient reaction kinetics, a solvent with high solubility such as an alcohol may be preferred.

In the pharmaceutical industry, the solubility of malonic acid in organic solvents can affect the formulation of drugs. It can influence the bioavailability and stability of the drug product. Additionally, in the production of polymers, the solubility of malonic acid in the reaction medium can impact the polymerization process and the properties of the resulting polymer.

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Contact for Purchase

If you are interested in purchasing malonic acid (CAS 141 - 82 - 2) or any of our other products, please feel free to contact us for more information and to start a procurement negotiation. We are committed to providing high - quality products and excellent customer service.

References

1. "The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals", 15th Edition.
2. "Handbook of Chemistry and Physics", 97th Edition.
3. Organic Chemistry textbooks, such as "Organic Chemistry" by Paula Y. Bruice.