2-Bromotoluene CAS 95-46-5

1. 2-Bromotoluene is widely used as a versatile building block in organic synthesis and pharmaceutical manufacturing, particularly for nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamic acid and mefenamic acid .
2. 2-Bromotoluene CAS 95-46-5 serves as a key intermediate in Suzuki coupling reactions and other cross-coupling methodologies to create complex organic molecules for drug discovery and material science applications .
3. Applications of 2-Bromotoluene also include its use as a solvent and reagent in studying substitution reaction mechanisms, as well as in the synthesis of polymers, coatings, and agrochemical intermediates .

1. Store 2-Bromotoluene in a tightly sealed container in a cool, dry, and well-ventilated place, away from heat, sparks, and open flames. Recommended storage temperatures vary from refrigeration (2-8 °C) to ambient conditions in a cool, dark location below 15°C .
2. Keep 2-Bromotoluene strictly away from strong oxidizing agents and strong bases to prevent hazardous reactions, and protect from light and moisture as the compound is hygroscopic and light-sensitive .
3. Always 2-Bromotoluene CAS 95-46-5 use appropriate personal protective equipment (PPE) including chemical-resistant gloves (rubber), safety goggles, and protective clothing; use only with adequate ventilation or in a fume hood to avoid breathing vapors.

1. Immediately isolate the spill area (at least 50 meters), eliminate all ignition sources, and contain 2-Bromotoluene using inert, non-combustible absorbent material (e.g., dry sand or earth); prevent material from entering drains or waterways .
2. Carefully collect 2-Bromotoluene CAS 95-46-5 using non-sparking tools (or explosion-proof vacuum) into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including self-contained breathing apparatus (SCBA) if necessary during cleanup; 2-Bromotoluene is classified for transport (UN 1993, Hazard Class 3, or UN 2811 Class 6.1 depending on jurisdiction) and requires hazardous waste disposal .

1. 2-Bromotoluene is classified as harmful if swallowed (H302), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Acute toxicity includes oral LD50 of 1540-1864 mg/kg (rat) and inhalation LC50 of 6800 mg/m³ (rat) .
2. 2-Bromotoluene is combustible with a flash point of 78-79°C (172-174°F) and autoignition temperature of 325°C; thermal decomposition produces toxic and corrosive fumes including hydrogen bromide, carbon monoxide, and carbon dioxide. It is toxic to aquatic life with long-lasting effects .
3. Always consult 2-Bromotoluene CAS 95-46-5 the specific Safety Data Sheet (SDS) for 2-Bromotoluene for complete hazard information (GHS signal word "Warning"), first-aid procedures (P305+P351+P338 for eyes, P301+P330+P331 for ingestion, P303+P361+P353 for skin), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P405 (store locked up) .