Triisopropylsilyl Chloride CAS 13154-24-0

1. Triisopropylsilyl chloride CAS 13154-24-0 is primarily used as a highly effective protecting group reagent for alcohols, amines, and phenols in organic synthesis, forming stable triisopropylsilyl (TIPS) ethers . Its three isopropyl groups provide strong steric screening, resulting in silyl ethers with exceptional stability under both basic and mildly acidic conditions, and allowing for selective protection of primary hydroxyl groups .
2. Triisopropylsilyl chloride serves as a crucial building block for silicon-based materials, including resins for marine antifouling paints and surface modifiers to enhance the hydrophobicity and chemical resistance of various substrates . It is also employed in the synthesis of silyl vinyl ketenes and other reactive intermediates .
3. Applications of Triisopropylsilyl chloride also include its role in analytical chemistry for preparing volatile derivatives for gas chromatography/mass spectrometry (GC/MS) , and as a reagent to sequester fluoride ions in catalytic reactions to suppress unwanted side reactivity .

1. Store Triisopropylsilyl chloride CAS 13154-24-0 in a tightly sealed container under an inert gas (e.g., argon) in a cool, dry, and well-ventilated place, as it is moisture-sensitive and hydrolyzes readily . Recommended storage temperatures include room temperature in a cool, dark place or refrigeration under argon .
2. Keep Triisopropylsilyl chloride strictly away from water, moisture, strong oxidizing agents, and strong bases. It is classified as a dangerous when wet material because contact with water evolves toxic and corrosive hydrogen chloride gas .
3. Always Triisopropylsilyl chloride use appropriate personal protective equipment (PPE) including tightly fitting safety goggles or face shield, chemical-resistant gloves, and protective clothing. Handle only with adequate ventilation or in a chemical fume hood, and avoid breathing vapors .

1. Immediately isolate the spill area, use full personal protective equipment including self-contained breathing apparatus (SCBA), and ensure adequate ventilation. Eliminate all ignition sources. Do NOT let Triisopropylsilyl chloride CAS 13154-24-0 enter drains or waterways .
2. Contain Triisopropylsilyl chloride using dry, inert, non-combustible absorbent material (e.g., dry sand). Absolutely avoid contact with water. Carefully collect the contaminated material using non-sparking tools into a sealed, labeled corrosion-resistant chemical waste container for proper disposal according to hazardous material regulations .
3. Personnel Triisopropylsilyl chloride must wear suitable PPE during cleanup. Triisopropylsilyl chloride is classified for transport as UN2987.

1. Triisopropylsilyl chloride is classified with GHS signal word "Danger". It causes severe skin burns and serious eye damage (H314/H318) and is harmful if inhaled, causing corrosive injuries to the upper respiratory tract and lungs . It is also considered a dangerous when wet material .
2. Triisopropylsilyl chloride has a flash point of 64°C , a boiling point of 198°C at 739 mmHg , and a vapor pressure of 1.16 mmHg at 20°C . It reacts violently with water, releasing toxic and corrosive hydrogen chloride gas .
3. Always Triisopropylsilyl chloride CAS 13154-24-0 consult the specific Safety Data Sheet (SDS) for Triisopropylsilyl chloride for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338+P310 for eyes, P304+P340+P310 for inhalation), and handling instructions. Precautionary statements include P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P310 (immediately call a poison center/doctor) .