2-Chlorobenzonitrile CAS 873-32-5

1. 2-Chlorobenzonitrile CAS 873-32-5 is an intermediate in the production of azo dyes and a precursor to 2-amino-5-nitrobenzonitrile, a dye precursor .
2. 2-Chlorobenzonitrile is widely used in pharmaceutical development, particularly for synthesizing anti-inflammatory and analgesic drugs, and as a building block for agrochemicals like herbicides and pesticides .
3. 2-Chlorobenzonitrile is an activated aryl chloride employed in palladium-catalyzed direct arylation reactions of heteroaromatics and is utilized in material science for specialty polymers .

1. Store 2-Chlorobenzonitrile  CAS 873-32-5 in a tightly sealed container in a cool, dry, well-ventilated area, with recommended temperatures between 0-8°C or -20°C for long-term stability .
2. Keep 2-Chlorobenzonitrile strictly away from strong oxidizing agents, strong acids, and strong bases to prevent hazardous reactions .
3. Handle 2-Chlorobenzonitrile using appropriate personal protective equipment including nitrile gloves, safety glasses, and in a fume hood, and avoid breathing dust and contact with skin and eyes .

1. Isolate the spill area, wear full protective equipment including self-contained breathing apparatus, and sweep up solid 2-Chlorobenzonitrile  CAS 873-32-5 into sealed, labeled containers without creating dust .
2. Prevent spilled 2-Chlorobenzonitrile from entering drains or waterways, as discharge into the environment must be strictly avoided .
3. Personnel cleaning 2-Chlorobenzonitrile spills must dispose of waste according to hazardous material regulations, as 2-Chlorobenzonitrile is classified for transport as an environmentally hazardous substance.

1. 2-Chlorobenzonitrile  CAS 873-32-5 is harmful if swallowed, harmful in contact with skin (H312, dermal LD50 rabbit: 340-600 mg/kg), and causes serious eye irritation (H319) with GHS signal word "Warning" .
2. 2-Chlorobenzonitrile has a flash point of 108-122°C, combustion produces toxic fumes including carbon monoxide, nitrogen oxides, and hydrogen chloride gas, and may form explosive mixtures with air on intense heating .
3. 2-Chlorobenzonitrile has a melting point of 43-48°C, boiling point of 232°C, and is slightly soluble in water (1g/l) .