3-Methyl-8-quinolinesulphonyl Chloride CAS 74863-82-4

1. 3-Methyl-8-quinolinesulfonyl chloride is primarily used as an organic synthesis intermediate and building block for preparing various complex molecules .
2. 3-Methyl-8-quinolinesulfonyl chloride CAS 74863-82-4 is notably identified as an impurity of the anticoagulant drug Argatroban and is used as a key intermediate in its preparation .
3. 3-Methyl-8-quinolinesulfonyl chloride is utilized in medicinal chemistry to synthesize sulfonamide derivatives with potential biological activity .

1. Store 3-Methyl-8-quinolinesulfonyl chloride in a tightly sealed container under an inert atmosphere, at refrigerated temperatures (0-8°C or -20°C for long-term), as it is moisture sensitive .
2. Keep 3-Methyl-8-quinolinesulfonyl chloride CAS 74863-82-4 strictly away from strong oxidizing agents, bases, and sources of moisture to prevent decomposition and hazardous reactions .
3. Handle 3-Methyl-8-quinolinesulfonyl chloride using appropriate personal protective equipment including chemical-resistant gloves and safety goggles, and work in a well-ventilated fume hood to avoid dust and vapor inhalation .

1. Isolate the spill area, wear full protective equipment including self-contained breathing apparatus, and contain solid 3-Methyl-8-quinolinesulfonyl chloride using dry inert absorbent material, preventing entry into drains or waterways .
2. Sweep up spilled 3-Methyl-8-quinolinesulfonyl chloride CAS 74863-82-4 into sealed, labeled containers for disposal according to hazardous material regulations .
3. Personnel cleaning 3-Methyl-8-quinolinesulfonyl chloride spills must dispose of waste as a corrosive material and avoid creating dust during cleanup operations.

1. 3-Methyl-8-quinolinesulfonyl chloride is corrosive (GHS05, Danger), causing severe skin burns and serious eye damage (H314/H318), with some reports indicating H319 and H335 hazards .
2. 3-Methyl-8-quinolinesulfonyl chloride CAS 74863-82-4 may cause damage to organs (H371) through exposure, is stable under recommended storage conditions, and melts at 158-159°C .
3. 3-Methyl-8-quinolinesulfonyl chloride is classified for transport as a corrosive solid (UN 3261, Hazard Class 8, Packing Group II) with WGK 1, and requires handling with precautionary statements including P260, P280, P301+P330+P331, and P305+P351+P338 .