2-(Trifluoromethyl)benzaldehyde CAS 447-61-0

1. 2-(Trifluoromethyl)benzaldehyde is primarily used as a versatile electrophilic component and key intermediate in organic synthesis, particularly for constructing complex molecules via reactions like the Wittig-Horner reaction . The electron-withdrawing trifluoromethyl group enhances its reactivity .
2. 2-(Trifluoromethyl)benzaldehyde CAS 447-61-0 serves as a crucial building block in the synthesis of pharmaceuticals, especially those targeting neurological and cardiovascular conditions , and plays a role in developing herbicides and pesticides .
3. Applications of 2-(Trifluoromethyl)benzaldehyde also include its use in materials science for creating advanced fluorinated aromatic polymers and coatings, and in analytical chemistry as a calibration standard .

1. Store 2-(Trifluoromethyl)benzaldehyde in a tightly sealed container under an inert gas (e.g., nitrogen or argon) in a cool, dry, well-ventilated place, protected from light, as 2-(Trifluoromethyl)benzaldehyde CAS 447-61-0 is air and moisture sensitive . Recommended storage is at room temperature in a cool, dark place (<15°C) or with refrigeration for long-term stability .
2. Keep 2-(Trifluoromethyl)benzaldehyde away from heat, sparks, open flames, strong oxidizing agents, and strong bases to prevent hazardous reactions .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing; handle only with adequate ventilation (fume hood) and avoid breathing vapors, mist, or dust .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation. Contain 2-(Trifluoromethyl)benzaldehyde using inert, non-combustible absorbent material (e.g., dry sand) and prevent material from entering drains or waterways .
2. Carefully collect 2-(Trifluoromethyl)benzaldehyde CAS 447-61-0 using an explosion-proof vacuum cleaner or wet brushing, and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-protective equipment and self-contained breathing apparatus (SCBA) if necessary during cleanup; in case of fire, use dry sand, dry chemical, or alcohol-resistant foam to extinguish .

1. 2-(Trifluoromethyl)benzaldehyde is classified as a combustible liquid (H227) with a flash point ranging from 52°C to 61°C (125-142°F) . It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . It is harmful if swallowed, inhaled, or in contact with skin (H302+H312+H332) .
2. 2-(Trifluoromethyl)benzaldehyde has a boiling point of 70-71°C at 16 mmHg, a melting point of -40°C, and a density of 1.32 g/mL at 25°C . Thermal decomposition or combustion produces toxic and irritating fumes, including carbon oxides and hydrogen fluoride . It is slightly soluble in water and classified for transport (UN1993, Hazard Class 3, PG III) .
3. Always consult 2-(Trifluoromethyl)benzaldehyde CAS 447-61-0 the specific Safety Data Sheet (SDS) for 2-(Trifluoromethyl)benzaldehyde for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P303+P361+P353 for skin, P304+P340 for inhalation), and handling instructions; precautionary statements include P210 (keep away from heat/sparks/open flames), P261 (avoid breathing vapors), and P280 (wear protective gloves/eye protection) .