3′-Chloroacetophenone CAS 99-02-5

1. 3'-Chloroacetophenone CAS 99-02-5 is primarily used as a key intermediate in the synthesis of various pharmaceuticals, including GABA-AT inhibitors, antimycobacterial agents, and chiral compounds for drug development . It is also employed in the production of agrochemicals and other technical products .
2. 3′-Chloroacetophenone serves as a versatile building block in organic synthesis, undergoing reactions such as bromination, condensation with diethyl carbonate, and biocatalytic reduction for the preparation of chiral alcohols .
3. Applications of 3'-Chloroacetophenone also include its use as a research chemical for developing new synthetic methodologies and studying biochemical processes .

1. Store 3'-Chloroacetophenone CAS 99-02-5 in a tightly sealed container in a cool, dry, well-ventilated area away from incompatible substances and sources of ignition . Recommended storage is at ambient temperatures .
2. Keep 3'-Chloroacetophenone away from strong oxidizing agents, and avoid contact with skin, eyes, and clothing .
3. Always use appropriate 3′-Chloroacetophenone personal protective equipment (PPE) including chemical-resistant gloves, protective clothing, and eye/face protection. Ensure adequate ventilation and use non-sparking tools to prevent fire caused by electrostatic discharge .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation. Contain 3'-Chloroacetophenone CAS 99-02-5 using inert, non-combustible absorbent material and prevent entry into drains or waterways .
2. Carefully collect 3′-Chloroacetophenone using spark-proof tools into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including self-contained breathing apparatus if necessary during cleanup. 3'-Chloroacetophenone is classified for transport and requires hazardous waste disposal .

1. 3'-Chloroacetophenone CAS 99-02-5 is classified as causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . The GHS signal word is **Warning** . NFPA health rating is 3 (short exposure could cause serious temporary or moderate residual injury) .
2. 3'-Chloroacetophenone has a flash point of 105°C (lit.) . Its thermal decomposition or combustion produces toxic and irritating fumes including carbon monoxide, carbon dioxide, and hydrogen chloride. It is harmful if swallowed (H302) .
3. Always consult 3′-Chloroacetophenone CAS 99-02-5 the specific Safety Data Sheet (SDS) for 3'-Chloroacetophenone for complete hazard information, first-aid procedures, and handling instructions. Precautionary statements include P261 (avoid breathing dust/fumes), P271 (use only in well-ventilated area), and P280 (wear protective gloves/eye protection) .