Diethyl Ethylmalonate CAS 133-13-1

1. Diethyl ethylmalonate is a key intermediate in the synthesis of HIV-1 reverse transcriptase inhibitors, highlighting its role in antiviral drug development . Diethyl ethylmalonate is also used in the preparation of Peloruside A, a novel antimitotic agent with potential as an anti-cancer drug .
2. Diethyl ethylmalonate CAS 133-13-1 acts as a crucial starting material in the asymmetric synthesis of (S)-α-arylthiomethyl-α-hydroxybutyric acid esters. These esters are important building blocks for constructing the E-ring unit of 20(S)-camptothecins, a class of anti-cancer agents .
3. Applications of Diethyl ethylmalonate also include its general use as a pharmaceutical raw material and an intermediate in the production of agrochemicals . Diethyl ethylmalonate CAS 133-13-1 participates in reactions such as microwave-assisted Michael additions and carbon monoxide trapping reactions, demonstrating its utility in developing efficient synthetic methodologies .

1. Store Diethyl ethylmalonate in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light and away from heat and open flames . Recommended storage temperatures are below 30°C or in a cool, dark place . Avoid prolonged exposure to air .
2. Keep Diethyl ethylmalonate away from strong oxidizing agents to prevent hazardous reactions or fire . Stable under normal temperatures and pressures .
3. Always Diethyl ethylmalonate CAS 133-13-1 use appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing when handling Diethyl ethylmalonate. Use with adequate ventilation, avoid generating vapors or mists, and wash thoroughly after handling .

1. Immediately contain the Diethyl ethylmalonate spill using inert, non-combustible absorbent material (e.g., dry sand, universal binder) and prevent entry into drains or waterways .
2. Carefully collect Diethyl ethylmalonate CAS 133-13-1 using non-sparking tools or an explosion-proof vacuum into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-resistant gloves and eye protection during cleanup. Ensure adequate ventilation and eliminate all ignition sources. The material is not classified as a dangerous good for transport by some regulations .

1. Diethyl ethylmalonate is classified as a combustible liquid (GHS H227) with a flash point of 88°C . It is classified by some sources as a flammable liquid (H227) with a warning signal word . It may be fatal if swallowed and enters airways (H304) .
2. Diethyl ethylmalonate may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335) . Thermal decomposition produces toxic and irritating fumes including carbon monoxide and carbon dioxide . It is harmful to aquatic life with long-lasting effects (H412) .
3. Always Diethyl ethylmalonate CAS 133-13-1 consult the specific Safety Data Sheet (SDS) for Diethyl ethylmalonate for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P301+P330+P331 for ingestion), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P240 (ground/bond container), and P280 (wear protective gloves/eye protection) .