Monoethyl Fumarate / MEF CAS 2459-05-4

1. Monoethyl fumarate is a fumaric acid ester used in dermatology; a mixture of Monoethyl fumarate salts (with dimethyl fumarate) is approved in Germany for treating moderate-to-severe plaque psoriasis .
2. MEF CAS 2459-05-4 serves as a functional monomer in synthesizing molecularly imprinted polymers (MIPs) for the selective separation of alkaloids like scopolamine via solid-phase extraction .
3. Monoethyl fumarate is used as a preservative and polymerization agent in high-molecular materials , and as a research tool for studying cellular stress response pathways (NRF2 activation) .

1. Store Monoethyl fumarate in a tightly sealed container in a cool, dry place . For long-term stability, store the powder at -20°C (up to 3 years) or 4°C (up to 2 years); solutions should be kept at -80°C .
2. Keep MEF CAS 2459-05-4 away from strong oxidizing agents and strong bases .
3. Handle Monoethyl fumarate using appropriate personal protective equipment, as Monoethyl fumarate may cause skin, eye, and respiratory irritation (H315, H319, H335) .

1. Isolate the MEF CAS 2459-05-4 spill area and wear personal protective equipment, including safety goggles and protective gloves .
2. Sweep up solid Monoethyl fumarate and place it into a sealed, labeled container for disposal; absorb solutions with inert material (e.g., diatomite) and decontaminate surfaces with alcohol .
3. Prevent Monoethyl fumarate from entering drains or waterways, and dispose of all waste according to local environmental regulations .

1. Monoethyl fumarate is classified with GHS signal word "Warning" and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) .
2. MEF CAS 2459-05-4 may be harmful if swallowed (H302) ; the toxicological properties of Monoethyl fumarate have not been fully investigated, and it should be handled as a moderate to severe irritant .
3. Under fire conditions, thermal decomposition of Monoethyl fumarate may produce toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides .