Aminoguanidine Hydrochloride CAS 1937-19-5

1. Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase (NOS) inhibitor, primarily used to reduce levels of advanced glycation end products (AGEs) by interacting with 3-deoxyglucosone .
2. Aminoguanidine hydrochloride CAS 1937-19-5 demonstrates selective inhibition of inducible nitric oxide synthase (iNOS, IC50=5.4 µM) over endothelial and neuronal NOS isoforms, making it valuable for studying inflammatory and neuropathic pain pathways .
3. Aminoguanidine hydrochloride has been investigated for treating diabetic nephropathy and shown beneficial effects on blood-retinal barrier breakdown in diabetic models .

1. Store Aminoguanidine hydrochloride  CAS 1937-19-5 powder at -20°C, desiccated, where it is stable for up to 3 years; solutions should be stored at -20°C and used within 1-3 months to prevent potency loss .
2. Keep Aminoguanidine hydrochloride away from strong oxidizing agents, strong acids, and strong bases due to incompatibility; protect from light and heat .
3. Handle Aminoguanidine hydrochloride using appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and in a fume hood, as Aminoguanidine hydrochloride is a moderate to severe irritant to skin and eyes .

1. Isolate the spill area, wear full protective equipment including NIOSH/MSHA-approved respirator, and avoid dust generation when handling solid Aminoguanidine hydrochloride CAS 1937-19-5.
2. Sweep up spilled Aminoguanidine hydrochloride using non-sparking tools into sealed, labeled containers for disposal; absorb solutions with inert material like diatomite and decontaminate surfaces by scrubbing with alcohol .
3. Prevent Aminoguanidine hydrochloride from entering drains or waterways, as environmental release should be avoided, and dispose of waste according to local regulations .

1. Aminoguanidine hydrochloride  CAS 1937-19-5 is classified with GHS signal word "Danger" and is harmful if swallowed (H302), causes skin irritation (H315), and causes serious eye damage/irritation.
2. Aminoguanidine hydrochloride may cause respiratory irritation (H335), is suspected of damaging fertility (R62) and causing harm to unborn child (R63); thermal decomposition produces toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides .
3. Aminoguanidine hydrochloride is soluble in water (>43 mg/mL) and DMSO (21 mg/mL), insoluble in ethanol, with a melting point of 163-164°C and molecular weight of 110.55 .