P-toluenesulfonyl Isocyanate CAS 4083-64-1

P-toluenesulfonyl isocyanate (CAS:4083-64-1) is an important organic raw materials.

Its main applications including:

1. P-toluenesulfonyl isocyanate is used as derivatization reagent for HPLC analysis of alcohols and primary amines.
2. P-toluenesulfonyl isocyanate is applied in fine chemical synthesis to introduce sulfonyl urea structural fragments.
3. P-toluenesulfonyl isocyanate serves as analytical labeling reagent for quantitative detection of trace active hydrogen compounds.

1. Store fully sealed under dry nitrogen at 0–5 °C in a lightproof cold storage cabinet.
2. Keep far away from water, alcohols, amines and all protic solvents to avoid violent reaction.
3. Isolate from heat sources, oxidants and acidic substances to prevent decomposition.

1. High reactivity for selective derivatization of hydroxyl and amine functional groups.
2. Produce stable sulfonyl urea derivatives convenient for chromatographic detection.
3. Low impurity content ensures high conversion rate in organic synthetic derivatization.

1. Strictly avoid inhalation, skin and eye contact; operate inside an exhausted fume hood with full chemical PPE.
2. Any contact with water releases irritating toxic gas; flush contaminated areas with anhydrous solvent first.
3. All residual liquid and waste must be treated as highly reactive hazardous chemical waste.