Sodium Trifluoroacetate CAS 2923-18-4

1. Sodium trifluoroacetate CAS 2923-18-4 is used as a trifluoromethylating agent for aromatic halides, aldehydes, and ketones, enabling the introduction of fluorine atoms to enhance biological activity and stability in drug development .
2. Sodium trifluoroacetate serves as a difluorocarbene precursor for alkenes and is utilized in acid-catalyzed reactions and as an intermediate for active pharmaceutical ingredients (APIs) .
3. Sodium trifluoroacetate acts as a buffer in biochemical assays to maintain pH for enzyme activity, as a derivatizing agent in mass spectrometry, and in the development of fluorinated polymers with chemical resistance for coatings .

1. Store Sodium trifluoroacetate CAS 2923-18-4 in a tightly sealed container under inert gas (argon) in a cool, dry place with recommended temperatures at room temperature (RT) in a dark spot below 15°C, as it is hygroscopic .
2. Keep Sodium trifluoroacetate strictly away from strong oxidizing agents, strong bases, and sources of moisture to prevent hazardous decomposition .
3. Handle Sodium trifluoroacetate using appropriate personal protective equipment including nitrile gloves, safety goggles, and in a fume hood to avoid dust formation and contact with skin and eyes .

1. Isolate the spill area, wear full protective equipment including suitable respirator, and sweep up solid Sodium trifluoroacetate CAS 2923-18-4 into sealed, labeled containers without creating dust .
2. Prevent spilled Sodium trifluoroacetate from entering drains or waterways, as it is very toxic to aquatic life with long-lasting effects (H400, H412) .
3. Personnel cleaning Sodium trifluoroacetate spills must dispose of waste according to environmental regulations and avoid release into the environment .

1. Sodium trifluoroacetate CAS 2923-18-4 is fatal if swallowed (H300) with GHS signal word "Danger" according to TCI, though other sources classify it as "Warning" with oral LD50 >7000 mg/kg in rats .
2. Sodium trifluoroacetate is very toxic to aquatic life with long-lasting effects (H400, H412) and requires precautionary statements P273 (avoid release to environment) and P391 (collect spillage) .
3. Sodium trifluoroacetate has a melting point of 205-207°C (dec.), density of 1.49 g/mL, is soluble in water (625 g/L at 20°C), and is not combustible, but thermal decomposition produces toxic fumes including carbon oxides, hydrogen fluoride, and sodium oxides .