Tri-tert-butylphosphine CAS 13716-12-6

1. Tri-tert-butylphosphine is a premier ligand in palladium-catalyzed cross-coupling reactions, enabling the use of aryl chlorides at room temperature by facilitating oxidative addition.
2. Tri-tert-butylphosphine CAS 13716-12-6 is key to reactions such as Suzuki, Negishi, Buchwald-Hartwig amination, Sonogashira, and Stille couplings, often allowing for mild conditions and broad substrate scope.
3. Tri-tert-butylphosphine is employed in the α-arylation of carbonyl compounds and in Heck reactions, serving as a fundamental tool in modern organic synthesis.

1. Store Tri-tert-butylphosphine under inert gas (e.g., argon) in a cool, dry place, as it is pyrophoric, air-sensitive, and moisture-sensitive.
2. Handle Tri-tert-butylphosphine CAS 13716-12-6 in a glove box or under a nitrogen flow; it is often purchased as a dilute solution (e.g., in hexanes or toluene) for easier and safer use.
3. Tri-tert-butylphosphine is classified as a dangerous good (UN 2846, Hazard Class 4.2, PG I). Wear appropriate PPE, including gloves and safety goggles, and avoid all contact with air and oxidizing agents.

1. Isolate the spill area immediately, eliminate all ignition sources, and evacuate personnel. Wear full protective equipment including a self-contained breathing apparatus due to the pyrophoric risk.
2. Do not allow contact with air. Use spark-proof tools and inert, non-combustible absorbent material (e.g., dry sand) to contain the material, then place it into a sealed, labeled container under inert atmosphere.
3. Prevent Tri-tert-butylphosphine CAS 13716-12-6 from entering drains or waterways. Dispose of all waste through a licensed hazardous waste facility.

1. Tri-tert-butylphosphine is classified with GHS signal word "Danger". It is a pyrophoric solid (H250) that can catch fire spontaneously if exposed to air, and it causes severe skin burns and eye damage (H314).
2. Tri-tert-butylphosphine CAS 13716-12-6 is a highly flammable solid (flash point -17°C) and may be fatal if swallowed and enters airways (H304).
3. Tri-tert-butylphosphine has an NFPA health rating of 3 (serious hazard) and a flammability rating of 4. Thermal decomposition produces toxic fumes including phosphorus oxides.