Tert-Butylchlorodiphenylsilane CAS 58479-61-1

1. Tert-Butylchlorodiphenylsilane CAS 58479-61-1 is primarily used as a bulky protecting group reagent for alcohols and amines in organic synthesis, forming stable TBDPS ethers that are resistant to acidic and mildly basic conditions . Tert-Butylchlorodiphenylsilane is notably employed to selectively protect primary and secondary alcohols and convert hemiacetals into ring-opened silyl ether carbonyl compounds .
2. The compound serves as a crucial silylation reagent and intermediate in pharmaceutical development, utilized in the synthesis of antibiotics, insecticides, vitamins, and intermediates for mono-O-protected pyrimidine acyclic nucleosides .
3. Applications of Tert-Butylchlorodiphenylsilane also include the preparation of silicon-based polymers and materials for electronics and coatings, and as a building block for advanced materials requiring enhanced thermal stability and mechanical strength .

1. Store Tert-Butylchlorodiphenylsilane CAS 58479-61-1 in a tightly sealed container under inert gas (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place, protected from light and moisture . Recommended storage temperatures range from 0-8°C (refrigerated) to a cool, dark place below 15°C . When stored in a strictly sealed and unopened container, it has a shelf life of 12 months .
2. Keep Tert-Butylchlorodiphenylsilane strictly away from moisture, strong oxidizing agents, strong acids, and strong alkalies, as contact may cause hazardous reactions .
3. Always Tert-Butylchlorodiphenylsilane use appropriate personal protective equipment (PPE) including tightly fitting safety goggles or face shield, chemical-resistant gloves, and protective clothing when handling Tert-Butylchlorodiphenylsilane. Use only with adequate ventilation or in a chemical fume hood, and avoid breathing vapors, mist, or gas .

1. Immediately isolate the spill area, use full personal protective equipment, and ensure adequate ventilation. Eliminate all ignition sources and contain Tert-Butylchlorodiphenylsilane CAS 58479-61-1 using dry, inert, non-combustible absorbent material (e.g., sand) .
2. Carefully sweep up or collect Tert-Butylchlorodiphenylsilane using non-sparking tools and place it into a sealed, labeled, corrosion-resistant chemical waste container for proper disposal according to local, state, and federal environmental regulations. Do NOT allow contact with water .
3. Personnel must wear suitable PPE including self-contained breathing apparatus (SCBA) during cleanup. Tert-Butylchlorodiphenylsilane is classified for transport and requires hazardous waste disposal .

1. Tert-Butylchlorodiphenylsilane CAS 58479-61-1 is classified with GHS signal word "Danger". It is corrosive, causing severe skin burns and serious eye damage (H314/H318), and may be corrosive to metals (H290) . The compound has an acid-like odor and can cause severe burns to mucous membranes and the upper respiratory tract .
2. Tert-Butylchlorodiphenylsilane is moisture sensitive and reacts with water, releasing corrosive hydrogen chloride gas. It has a flash point of 112°C (234°F) and autoignition temperature of 480°C (896°F) . Thermal decomposition produces toxic and irritating fumes including hydrogen chloride, carbon monoxide, carbon dioxide, and silicon dioxide .
3. Always Tert-Butylchlorodiphenylsilane CAS 58479-61-1 consult the specific Safety Data Sheet (SDS) for Tert-Butylchlorodiphenylsilane for complete hazard information, first-aid procedures, and handling instructions . Precautionary statements include P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P405 (store locked up) . WGK Germany rating is 3 (high hazard to waters) .