Trimethylsulfoxonium Iodide CAS 1774-47-6

1. Trimethylsulfoxonium iodide CAS 1774-47-6 is primarily used to synthesize dimethyloxosulfonium methylide, a key methylene-transfer reagent for converting carbonyl compounds into epoxides and α,β-unsaturated esters into cyclopropyl esters . It is also an essential reagent in an improved protocol for synthesizing carbonyl sulfoxonium ylides from carboxylic acid derivatives .
2. Trimethylsulfoxonium iodide serves as a powerful methylating agent in synthetic chemistry for introducing methyl groups into various organic compounds . It is employed in the synthesis of sulfoxides and sulfones, which are important intermediates for agrochemicals and fine chemicals .
3. Applications of Trimethylsulfoxonium iodide also include its use in pharmaceutical development, notably as an intermediate in the synthesis of the antifungal drug fluconazole , and in biochemistry for studying methylation processes in biological systems .

1. Store Trimethylsulfoxonium iodide CAS 1774-47-6 in a tightly sealed container under inert gas protection in a cool, dry, and well-ventilated place . Recommended storage temperatures range from 0-8°C (refrigerated) to ambient conditions in a cool, dark place, as it is light-sensitive .
2. Keep Trimethylsulfoxonium iodide strictly away from strong oxidizing agents and strong bases, which are incompatible materials . Protect from light and moisture, and avoid water ingress into containers as it may cause a violent reaction .
3. Always Trimethylsulfoxonium iodide use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, and protective clothing . Handle with adequate ventilation, avoid dust formation, and wash thoroughly after handling .

1. Immediately isolate the spill area, use personal protective equipment, and avoid generating dust . Contain Trimethylsulfoxonium iodide CAS 1774-47-6 using inert, non-combustible absorbent material and prevent entry into drains or waterways .
2. Carefully sweep up or vacuum the spilled solid using appropriate methods and place the collected material into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel Trimethylsulfoxonium iodide must wear suitable PPE, including self-contained breathing apparatus (SCBA) if necessary, during cleanup . Under fire conditions, decomposition products include toxic and irritating fumes such as carbon oxides, sulfur oxides, and hydrogen iodide .

1. Trimethylsulfoxonium iodide CAS 1774-47-6 is classified with GHS signal word "Warning". It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . Acute oral LD50 in rats is >2000 mg/kg .
2. Trimethylsulfoxonium iodide has a melting point range of 208-212°C (dec.) and is soluble in water (approximately 15-50 g/L) . It is toxic to aquatic life with long-lasting effects (H411, H412) and is not classified as a dangerous good for transport by some regulations .
3. Always Trimethylsulfoxonium iodide CAS 1774-47-6 consult the specific Safety Data Sheet (SDS) for Trimethylsulfoxonium iodide for complete hazard information, first-aid procedures, and handling instructions. Precautionary statements include P261 (avoid breathing dust), P273 (avoid release to environment), and P280 (wear protective gloves/eye protection) .