2 3-Dibromo-5-chloropyridine CAS 137628-17-2

1. 2,3-Dibromo-5-chloropyridine CAS 137628-17-2 is primarily used as a key intermediate in organic synthesis and pharmaceutical manufacturing, particularly for preparing pyridine-based drug molecules such as Ubrogepant .
2. 2 3-Dibromo-5-chloropyridine serves as a versatile building block with tri-reactive halogens (two bromines and one chlorine), enabling sequential and selective functionalization through cross-coupling reactions for synthesizing complex heterocyclic compounds .
3. 2,3-Dibromo-5-chloropyridine is employed as a laboratory reagent for studying reaction mechanisms in pyridine derivative synthesis, where the 2-position bromine exhibits higher reactivity than the 5-position bromine due to the electron-deficient nature of the pyridine ring .
4. Researchers utilize 2 3-Dibromo-5-chloropyridine in agrochemical development and material science applications, including as a photosensitizer in printing and photo production processes .

1. 2,3-Dibromo-5-chloropyridine CAS 137628-17-2 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture, with storage temperatures ranging from room temperature (inert atmosphere) to 2-8°C depending on stability requirements .
2. 2 3-Dibromo-5-chloropyridine should be kept separate from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to avoid decomposition, and stored away from heat sources and open flames .
3. Personnel must wear chemical-resistant gloves (rubber), safety goggles with side-shields, and protective clothing when handling 2,3-Dibromo-5-chloropyridine, as 2 3-Dibromo-5-chloropyridine causes skin and serious eye irritation (Hazard statements H315, H319) .
4. Avoid inhalation of dust particles, ensure adequate ventilation in work areas (preferably a chemical fume hood), wash thoroughly after handling, and follow safety statements S26 (eye contact: rinse immediately with water and seek medical advice) and S37 (wear suitable gloves) .

1. Isolate the spill area, ensure adequate ventilation, and avoid dust formation when 2,3-Dibromo-5-chloropyridine CAS 137628-17-2 is released, wearing full personal protective equipment including rubber gloves, airtight goggles, and protective clothing .
2. Collect 2 3-Dibromo-5-chloropyridine by sweeping or vacuuming without creating dust, or use inert absorbent materials, and place into suitable closed containers for disposal, taking care not to disperse the powder .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, and decontaminate surfaces and equipment using appropriate methods, ensuring spilled material does not enter drains or water courses .
4. Dispose of collected 2 3-Dibromo-5-chloropyridine material according to local, state, and federal environmental regulations, preferably through licensed chemical destruction or controlled incineration in a chemical incinerator equipped with afterburner and scrubber .

1. 2,3-Dibromo-5-chloropyridine CAS 137628-17-2 is not classified as highly flammable but may decompose under fire conditions, with a flash point of approximately 111°C and may emit toxic fumes when involved in a fire .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product, selecting appropriate extinguishing 2 3-Dibromo-5-chloropyridine media based on surrounding environment .
3. Firefighters should wear self-contained breathing apparatus and full protective gear when handling burning 2,3-Dibromo-5-chloropyridine due to hazardous decomposition gases including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), hydrogen chloride, and hydrogen bromide .
4. During combustion, may 2 3-Dibromo-5-chloropyridine emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination .