5-Benzylthio-1H-tetrazole CAS 21871-47-6

5-Benzylthio-1H-tetrazole (CAS:21871-47-6) is an important pharmaceutical intermediates.

Its main applications including:

1. Key sulfur-containing tetrazole intermediate for synthesizing cardiovascular and anti-infective drugs.
2. 5-Benzylthio-1H-tetrazole is widely adopted raw material for preparing catalyst ligands and heterocyclic fine chemicals.
3. 5-Benzylthio-1H-tetrazole is used as corrosion inhibitor additive and analytical standard for tetrazole derivative detection.

1. Store in fully sealed containers below 25°C in dry dark storage to prevent photodegradation of tetrazole and thioether groups.
2. Avoid strong friction, impact and overheating to lower decomposition risk of nitrogen-rich heterocycle.
3. Store separately from strong oxidants, heavy metal salts and concentrated acid reagents.

1. Avoid inhalation of fine crystalline dust; wear dust mask and chemical resistant gloves during weighing and transfer.
2. Do not ingest the solid; flush exposed eyes and skin with abundant running water after accidental contact.
3. Dispose waste residues and reaction filtrate complying with sulfur-nitrogen heterocyclic hazardous waste regulations.

1. Controllable benzylthio substituent enables selective deprotection and coupling in synthetic routes.
2. Stable tetrazole skeleton maintains structural integrity under mild heating reaction environments.
3. High crystalline purity effectively suppresses miscellaneous byproducts in drug intermediate manufacturing.