6-Quinolinylmethanol CAS 100516-88-9

1. 6-Quinolinylmethanol is primarily used as a pharmaceutical intermediate in medicinal chemistry, particularly for the synthesis of drug candidates such as those patented for therapeutic applications (e.g., US2003/212100 A1) .
2. 6-Quinolinylmethanol CAS 100516-88-9 serves as a versatile building block for preparing quinoline-based bioactive molecules, antimicrobial agents, and kinase inhibitors in drug discovery research .
3. 6-Quinolinylmethanol is employed as a research compound for developing heterocyclic derivatives, where its hydroxymethyl group provides a reactive handle for further functionalization and elaboration into complex molecular architectures .
4. Researchers utilize 6-Quinolinylmethanol CAS 100516-88-9 for R&D purposes only, leveraging its quinoline scaffold which is a privileged structure found in numerous natural alkaloids and synthetic pharmaceuticals with antimalarial, anticancer, antibacterial, and anti-inflammatory activities .

1. 6-Quinolinylmethanol must be stored in a tightly sealed container under inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated environment, protected from light, with recommended storage at room temperature in a dark place or at 2-8°C for stability .
2. 6-Quinolinylmethanol CAS 100516-88-9 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), and H412 (Harmful to aquatic life with long-lasting effects), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, face protection, and protective clothing when handling 6-Quinolinylmethanol, ensuring adequate ventilation in work areas (preferably a chemical fume hood) and avoiding formation of dust and aerosols .
4. Avoid inhalation of dust particles, prevent contact with skin, eyes, and clothing, wash thoroughly after handling, and follow precautionary statements P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P337+P313, P362+P364, P403+P233, P405, and P501 .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable respirator when 6-Quinolinylmethanol is released, evacuating non-essential personnel .
2. Collect 6-Quinolinylmethanol CAS 100516-88-9 by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, decontaminate surfaces using appropriate methods, and prevent the product from entering drains or water courses due to aquatic toxicity hazards .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration, following disposal considerations outlined in safety data sheets .

1. 6-Quinolinylmethanol is not classified as highly flammable but may decompose under fire conditions, with a flash point of 156.3±20.9°C and boiling point of 334.8±17.0°C at 760 mmHg, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) when involved in a fire .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use water jet as it may spread burning material .
3. Firefighters 6-Quinolinylmethanol CAS 100516-88-9 should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 6-Quinolinylmethanol due to hazardous decomposition gases generated by thermal decomposition or combustion .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, contain fire runoff to prevent environmental contamination, and collect contaminated fire extinguishing water separately .