Caulophyllogenin CAS 52936-64-8

1. Caulophyllogenin CAS 52936-64-8 is a pentacyclic triterpenoid compound that functions as a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ), with an EC50 of 12.6 μM .
2. Caulophyllogenin exhibits anti-inflammatory properties by inhibiting the secretion of pro-inflammatory cytokines, including IL-12 p40, IL-6, and TNF-α, with IC50 values ranging from 3.3 to 20.0 μM .
3. Caulophyllogenin is utilized in research for the potential prevention and treatment of inflammatory diseases, type-2 diabetes, obesity, and metabolic syndrome .
4. Researchers employ Caulophyllogenin as a reference standard and natural product isolate derived from plant sources such as *Caulophyllum robustum* and *Kalopanax pictus* (Araliaceae) .

1. Caulophyllogenin CAS 52936-64-8 powder must be stored in a tightly sealed container at -20°C for long-term stability (up to 3 years) or at 4°C for up to 2 years, protected from light and moisture .
2. For solution storage, prepare aliquots in DMSO and store at -80°C for up to 6 months or at -20°C for up to 1 month, avoiding repeated freeze-thaw cycles to prevent degradation.
3. Personnel Caulophyllogenin must wear chemical-resistant gloves, safety goggles with side-shields, and impervious protective clothing when handling Caulophyllogenin; use suitable respiratory protection in areas with dust generation .
4. The compound is classified as non-hazardous under normal handling conditions according to GHS criteria, with no known carcinogenicity or reproductive toxicity concerns .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Caulophyllogenin is released .
2. For Caulophyllogenin solid spills, collect the spilled product by sweeping or vacuuming without creating dust using non-sparking tools; for solutions, absorb with finely-powdered liquid-binding materials such as diatomite or universal binders .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Prevent the product from entering drains, water courses, or the soil; dispose of collected material according to local, state, and federal environmental regulations .

1. Caulophyllogenin CAS 52936-64-8 is not classified as highly flammable but may decompose under fire conditions, emitting irritant fumes .
2. Use Caulophyllogenin water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Caulophyllogenin due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .