2-Pyridylacetic Acid Hydrochloride CAS 16179-97-8

1. 2-Pyridylacetic acid hydrochloride is primarily used as a key reference standard and metabolite in pharmaceutical research, most notably as the primary, pharmacologically inactive metabolite of the anti-vertigo drug betahistine .
2. 2-Pyridylacetic acid hydrochloride CAS 16179-97-8 is essential for pharmacokinetic studies, where its plasma concentration serves as a critical biomarker for assessing betahistine absorption, bioavailability, and disposition using LC-MS and HPLC methods .
3. 2-Pyridylacetic acid hydrochloride is employed in analytical chemistry for developing separation methods for structural isomers (2-, 3-, and 4-pyridylacetic acid) using mixed-mode chromatography, and functions as a building block in nucleophilic substitution reactions for synthesizing complex heterocyclic compounds .
4. Researchers utilize 2-Pyridylacetic acid hydrochloride CAS 16179-97-8 in drug discovery for synthesizing and testing derivatives with potential inhibitory activity toward enzymes involved in steroidogenesis and as a reactant for preparing compounds with antimicrobial and antiviral properties .

1. 2-Pyridylacetic acid hydrochloride must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light; due to its hygroscopic nature, storage under inert atmosphere at -20°C freezer is recommended for long-term stability .
2. 2-Pyridylacetic acid hydrochloride CAS 16179-97-8 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with risk phrase R 36/37/38 and signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and minimizing dust generation and accumulation .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling, remove contaminated clothing before reuse, and avoid ingestion and inhalation .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95 or P1 filter) when 2-pyridylacetic acid hydrochloride is released .
2. Vacuum 2-Pyridylacetic acid hydrochloride CAS 16179-97-8 or sweep up the spilled product without creating dust using non-sparking tools, and place into suitable closed containers for disposal, cleaning up spills immediately using appropriate protective equipment .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; provide adequate ventilation; prevent the product from entering drains or water courses as discharge into the environment must be avoided (WGK Germany 3 - high water hazard potential) .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration, noting that runoff from fire control or dilution water may cause pollution .

1. 2-Pyridylacetic acid hydrochloride is combustible with a flash point not applicable (solid) and decomposes at approximately 130-160°C depending on the source; under fire conditions, hazardous decomposition products include toxic fumes of hydrogen chloride, nitrogen oxides (NOx), carbon monoxide, carbon dioxide, and irritating and toxic gases .
2. Use 2-Pyridylacetic acid hydrochloride CAS 16179-97-8 water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product, selecting the agent most appropriate to extinguish the fire .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-pyridylacetic acid hydrochloride due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .